Ginseng extract CAS 90045-38-8
Introduction：Basic information about Ginseng extract CAS 90045-38-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Ginseng extract Basic information
| Product Name: | Ginseng extract |
| Synonyms: | GINSENG, SIBERIAN;GINSENG EXTRACT;Total Ginsenoside;ginsenoside from ginseng root;Ginseng america;Ginseng, Panax quinquefolium, ext.;Ginseng Monosomic saponins Rh,;Oriental Ginseng P.E |
| CAS: | 90045-38-8 |
| MF: | C15H24N2O |
| MW: | 248.37 |
| EINECS: | 289-898-5 |
| Product Categories: | Natural Plant Extract;Plant extract;cosmetic |
| Mol File: | Mol File |
Ginseng extract Chemical Properties
| Odor | at 100.00 %. linalool citrus fresh |
| Odor Type | citrus |
| Cosmetics Ingredients Functions | ASTRINGENT ANTIOXIDANT SKIN CONDITIONING |
| Cosmetic Ingredient Review (CIR) | Ginseng extract (90045-38-8) |
Safety Information
| HS Code | 2938900000 |
| Occurrence | Ginseng is now found throughout the world. Panax quinquefolius is native to North America; Panax ginseng is native to the Far East. |
| Uses | ginseng extract (Panax sp.) is considered tonic and nourishing because of its vitamin and hormone content. It seems to aid in diminishing wrinkles and helps dry skin. It is also said to promote skin elasticity, perhaps by stimulating sterol and protein production. other claims include skin rejuvenating, oxygenating, and stimulating properties. Folkloric remedies cite use for boils, bruises, sores, and swellings. This root’s active components are called ginsenosides and these are said to be responsible for revitalizing and reactivating epidermal cells. other important constituents include saponins, mucin, and vitamin B. The extract comes from the root. ginseng has been associated with many allergic skin reactions. |
| Indications | Panax ginseng describes the root from two species ofplants, Asian ginseng (Panax ginseng) and American ginseng(Panax quinquefolius), popularly used for improvingstamina and providing a sense of well-being. The terms red and white ginseng refer to how the root isprocessed, not the species of origin. Red ginseng roots aresteam-cured prior to drying, while white ginseng isbleached and dried. Panax ginsengs contain triterpenoidsaponins called ginsenosides (also called panaxosides), ofwhich up to 18 types are recognized as having differingand sometimes opposing pharmacological properties. Siberian ginseng (Eleutherococcus senticosus)should not be confused with Panax ginseng.Although itbelongs to the same plant family (Araliaceae), it is amuch larger, more abundant, and consequently less expensiveplant. Like Panax ginseng, however, it is used asa tonic and adaptogen, a nonmedical term meaning thatit helps the body adapt to stress in a variety of ways.Siberian ginseng does contain saponins (eleutherosides)but no ginsenosides. To date, in spite of its popularity,there is little conclusive evidence of clinical efficacy. |
| General Description | Major components are named the ginsenosides. The chemical constituents of ginseng are called ginsenosides or panaxosides. A total of 12 of these have been isolated but are present in such small quantities that purification is difficult. Sterols, flavonoids, proteins, and vitamins (B1, B2, B12, pantothenic acid, niacin, and biotin) are also components with pharmacological activity. The chemistry of ginseng gives a good example of how different compounds in one herb can have opposing pharmacological effects. Ginsenoside Rb-1 acts as a CNS depressant, anticonvulsant, analgesic, and antipsychotic, prevents stress ulcers, and accelerates glycolysis and nuclear RNA synthesis. Ginsenoside Rg-1 stimulates the CNS, combats fatigue, is hypertensive, and aggravates stress ulcers. Additionally, ginsenosides Rg and Rg-1 enhance cardiac performance, whereas Rb depresses that function. Some of the other ginsenosides display antiarrhythmic activity similar to that of the calcium channel blocker verapamil and amiodarone. Ginseng is popularly believed to enhance concentration, stamina, alertness, and the ability to do work. Longer-term use in elderly patients is claimed to enhance “well-being.”. |
| Mechanism of action | Ginsenosides are thought to be the active principles inPanax ginseng root. The various subtypes can have opposingpharmacological actions: Rg1 stimulates the centralnervous system (CNS) and elevates blood pressure,while Rb1 does just the opposite. Somehow these multipleginsenoside constituents are thought to act in concertto provide increased stamina. In addition, thesecompounds have antiplatelet aggregation effects andantioxidant properties, and they may stimulate the immunesystem. |
| Anticancer Research | Ginseng can refer to either white or red ginseng, and herbal preparations varyaccording to the type. In European herbal medicine, ginseng is powdered into300 mg/capsule, with 2–3 capsule/day dosage (Lust 2014). For ginseng in dryextract, 15 ml of oral liquid is given once daily. Each 15 ml of oral liquid contains140 mg of dry extract (Kapoor 2000). American ginseng is also listed as an ingredientin some soft drinks, and its oil and extracts are used in soap and cosmetics(Gupta et al. 2004). There is a little evidence in terms of clinical research to supportginseng treating breast cancer (Shin et al. 2000). However, research conducted inChina suggests that patients treated with any form of ginseng maintained betterpsychological condition. Thus, it might be more appropriate to say it has benefits interms of supporting and minimising damage from the cancer drug tamoxifen intreatment (Cui et al. 2006). |
| Clinical Use | Despite the long popularity of ginseng and its evidentmild stimulatory effect, there is less conclusive evidencefor its clinical effectiveness than for many of the otherherbs discussed in this chapter. In regard to improvingcognitive function, most studies have failed to prove aconsistent benefit. A recent investigation of ginseng’seffect on physical stamina found that an 8-week courseof therapy failed to improve aerobic work capacity.Ginseng has been studied as a diabetic agent, with reducedhemoglobin A1c levels and improved glucosecontrol being documented in a small trial. Althoughthere is some intriguing work with ginseng as a cancerpreventive, there is not enough evidence to suggest itsclinical use at this time. |
| Side effects | Ginseng is generally considered safe for nonpregnanthealthy adults; however, at sufficient doses, ginseng mayelevate blood pressure and cause insomnia, palpitations,nervousness, and tremor in susceptible individuals.These effects are increased if caffeine or other stimulantsare taken concurrently. Both Panax and Siberianginsengs should definitely be avoided in any patientwith poorly controlled hypertension. Dizziness,headache, diarrhea, and nausea have also been reported.A controversial ginseng abuse syndrome consistingof tremor, elevated blood pressure, insomnia,and anxiety may also occur. Diabetic patients have had hypoglycemia on ginseng,so sugars must be monitored, and insulin or other hypoglycemicmedication dosages may have to be reduced.The use of ginseng with anticoagulants (e.g., warfarin) andantiplatelet drugs is to be avoided because of the theoreticalrisk of increased bleeding. Also, coadministration ofginseng with digoxin and MAOIs should be avoided. |
Ginseng extract Preparation Products And Raw materials
| Preparation Products | Ginsenoside Re-->Fumaric acid-->β-Caryophyllene-->PANASENOSIDE-->Ginsenoside Ra1 |
