Ginkgolide C CAS 15291-76-6

Introduction：Basic information about Ginkgolide C CAS 15291-76-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Ginkgolide C Basic information

• Product Name: Ginkgolide C
• Synonyms: GINKGOLIDE C;1,7-DIHYDROXY-GINKGOLIDE A;(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione;Gingkolide C;bn52022;GinkgolideA,1,7-dihydroxy-, (1α,7β)-;CGinkgolid;Ginkgolide C, 98%, from Ginkgo biloba L.
• CAS: 15291-76-6
• MF: C20H24O11
• MW: 440.4
• Product Categories: Pharmaceuticals;Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Intermediates & Fine Chemicals;Saponins
• Mol File: 15291-76-6.mol

Ginkgolide C Chemical Properties

• Melting point: >3000 (dec)
• alpha: D24 -14.7° (c = 1 in ethanol)
• Boiling point: 813.8±65.0 °C(Predicted)
• density: 1.72±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Heated)
• form: Solid
• pka: 10.88±0.70(Predicted)
• color: White to Off-White
• InChIKey: AMOGMTLMADGEOQ-WCHJOOGENA-N
• LogP: 1.719 (est)

Safety Information

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• HS Code: 29322090

Ginkgolide C Usage And Synthesis

Description

Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC₅₀ = 37.6 μM). Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.

Chemical Properties

Crystalline Solid

Uses

Reference compound for PAF receptors in biological systems.

Uses

Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.

IC 50

AMPK; MMP-9; Sirtuin

References

[1] PIERRE BRAQUET. Recent progress in ginkgolide research[J]. Medicinal Research Reviews, 1991, 11 3: 295-355. DOI: 10.1002/med.2610110303
[2] CHIAN-JIUN LIOU. Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway.[J]. Evidence-based Complementary and Alternative Medicine, 2015: 298635. DOI: 10.1155/2015/298635

Ginkgolide C Preparation Products And Raw materials

• Raw materials: 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-2,7b,11-trihydroxy-8-methyl-4-(phenylmethoxy)-, (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-
• Preparation Products: Ginkgolide B