Ginsenoside Rb3 CAS 68406-26-8

Introduction：Basic information about Ginsenoside Rb3 CAS 68406-26-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Ginsenoside Rb3 Basic information

• Product Name: Ginsenoside Rb3
• Synonyms: glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl6-o-beta-d-xylopyranosyl-;Ginsenoside Rb3 (CAS#68403-26-8);Gypenoside IV;hydroxydammar-24-en-20-yl6-O-β-D-;xylopyranosyl-;β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D-;[3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-12β-hydroxy-5α-dammar-24-en-20-yl]6-O-(β-D-xylopyranosyl)-β-D-glucopyranoside;GINSENOSIDE Rb3(SH)
• CAS: 68406-26-8
• MF: C53H90O22
• MW: 1079.27
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Ginsenoside series
• Mol File: 68406-26-8.mol

Ginsenoside Rb3 Chemical Properties

• Melting point: 193～195℃
• Boiling point: 1117.1±65.0 °C(Predicted)
• density: 1.42±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
• pka: 12.85±0.70(Predicted)
• form: Solid
• color: White
• Water Solubility: insoluble in water
• Stability: Hygroscopic
• InChIKey: NODILNFGTFIURN-OKKVPZHQSA-N
• CAS DataBase Reference: 68406-26-8

Safety Information

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: LZ5857000
• HS Code: 29389090
• Storage Class: 13 - Non Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral

Ginsenoside Rb3 Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng and Gynostemma pentaphyllum.

Uses

Ginsenoside Rb3 inhibits the upregulation of phospho-IκB-α and nuclear translocation of NF-κB subunit p65 induced by glucose deprivation then reperfusion.

in vivo

Ginsenosides Rb3 is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment and induces anti-polyposis in Apc^Min/+ mice. Six-weeks-old mice are subjected to Rb3 treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Rb3 treatments^[3].

IC 50

NF-κB: 8.2 μM (IC₅₀, in 293T cell lines); iNOS; COX-2