Introduction：Basic information about Glyphosine CAS 2439-99-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Glyphosine Basic information
| Product Name: | Glyphosine |
| Synonyms: | GLYCINE-N,N-BIS(METHYLENEPHOSPHONIC ACID);Polaris(monsanto);Glyphosphine;polaris;N,N-bis phophonomethyl glycine;glyphosine (ISO) N,N-bis(phosphonomethyl)glycine;2-(Bis(phosphonomethyl)amino)acetic acid;N,N-Di(phosphonomethyl)glycine |
| CAS: | 2439-99-8 |
| MF: | C4H11NO8P2 |
| MW: | 263.08 |
| EINECS: | 219-468-4 |
| Product Categories: | PLANT GROWTH REGULATOR;Analytical Chemistry;Chelating Reagents;Complexones;EDTA Analogs |
| Mol File: | 2439-99-8.mol |
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Glyphosine Chemical Properties
| Melting point | 263°C |
| Boiling point | 668.4±65.0 °C(Predicted) |
| density | 1.952±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | PBS (pH: 7.2):5.0(Max Conc. mg/mL);19.01(Max Conc. mM) |
| form | Solid |
| pka | pK1 1.42; pK2 2.10; pK3 5.02; pK4 6.40; pK5 11.19(at 25℃) |
| color | White |
| Water Solubility | 248g/L(20 ºC) |
| Merck | 13,4526 |
| BRN | 1884944 |
| InChI | InChI=1S/C4H11NO8P2/c6-4(7)1-5(2-14(8,9)10)3-15(11,12)13/h1-3H2,(H,6,7)(H2,8,9,10)(H2,11,12,13) |
| InChIKey | OXHDYFKENBXUEM-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CN(CP(O)(O)=O)CP(O)(O)=O |
| CAS DataBase Reference | 2439-99-8(CAS DataBase Reference) |
| EPA Substance Registry System | Glyphosine (2439-99-8) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 41 |
| Safety Statements | 26-2 |
| RIDADR | UN 3261 8/PG 3 |
| WGK Germany | 1 |
| RTECS | MB9120000 |
| TSCA | TSCA listed |
| HS Code | 2922.49.8000 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 |
| Toxicity | LD50 orally in rats: 3925 mg/kg; dermally in rabbits: >5010 mg/kg (Ahlrichs) |
Glyphosine Usage And Synthesis
| Description | Glyphosine was introduced in 1973 and is preferably used in sugar beets. The synthesis starting with glycine uses two equivalents of formaldehyde and of phosphorous trichloride under oxidative conditions. A second derivative of Glyphosate is a cyclic phosphaoxazole being formed from Glyphosate and formaldehyde. This compound is claimed to control the growth of some grasses without dis- coloration or phytotoxicity.
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| Uses | Chemical ripener; plant growth regulator. |
| Uses | Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89
Anti-diabetic; delay onset of diabetes in non-obese NOD mice
Glyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice. |
| Definition | ChEBI: A tertiary amino compound that consists of glycine bearing two N-phosphonomethyl substituents. |
| General Description | N,N-Bis(phosphonomethyl)glycine was present in the ligand bound to human apotransferrin. |
| Biochem/physiol Actions | Anti-diabetic; delay onset of diabetes in non-obese NOD mice |
Glyphosine Preparation Products And Raw materials
| Raw materials | Phosphorus trichloride-->Glycine-->Propanil-->METHYLPHOSPHONIC ACID-->Glyphosate-->GLYPHOSATE-N-METHYL |
| Preparation Products | PhosphonoMethanol |
