Halofantrine hydrochloride CAS 36167-63-2

Introduction：Basic information about Halofantrine hydrochloride CAS 36167-63-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Halofantrine hydrochloride Basic information

• Product Name: Halofantrine hydrochloride
• Synonyms: Halfan;D02485;Halfan (tn);Halofantrine hydrochloride (usan);Halofantarine HCL;Halfan, 1,3-Dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride;1,3-dichloro-alpha-[2-(dibutylamino)ethyl]-6- (trifluoromethyl)-9-phenathrenemethanol hydrochloride;halofantrine hydrochloride
• CAS: 36167-63-2
• MF: C26H30Cl2F3NO.ClH
• MW: 536.89
• EINECS: 252-895-4
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 36167-63-2.mol

Halofantrine hydrochloride Chemical Properties

• Melting point: 93-96°; mp 203-204°
• storage temp.: 2-8°C
• solubility: DMSO: >10mg/mL
• form: solid
• color: white to off-white
• Major Application: pharmaceutical (small molecule)
• InChI: 1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
• InChIKey: WANGFTDWOFGECH-UHFFFAOYSA-N
• SMILES: Cl.CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F
• CAS DataBase Reference: 36167-63-2(CAS DataBase Reference)

Safety Information

• WGK Germany: 3
• RTECS: SF7790000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Chronic 4

Halofantrine hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Uses

halofantrine, a drug that is effective against chloroquine-resistant malaria and is now being evaluated in Africa.

Uses

Antimalarial.

Brand name

Halfan (GlaxoSmithKline).

Biological Activity

Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel.

IC 50

Plasmodium