Introduction：Basic information about Hecogenin CAS 467-55-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Hecogenin Basic information
| Product Name: | Hecogenin |
| Synonyms: | HECOGENIN;5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL-12-ONE;5ALPHA-SPIROSTAN-3BETA-OL-12-ONE;3BETA-HYDROXY-5ALPHA-SPIROSTAN-12-ONE;25R,5ALPHA-SPIROSTAN-3BETA-OL-12-ONE;Hecoginin;(25R)-5-Spirostan-3-ol-12-one;(3,5,25R)-3-Hydroxysiprostan-1 |
| CAS: | 467-55-0 |
| MF: | C27H42O4 |
| MW: | 430.62 |
| EINECS: | 207-392-4 |
| Product Categories: | 467-55-0;Biochemistry;Steroids (Others);Steroids |
| Mol File: | 467-55-0.mol |
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Hecogenin Chemical Properties
| Melting point | 268°C |
| alpha | 7.2 º (c=0.8 g/100ml, CHCl3) |
| Boiling point | 464.85°C (rough estimate) |
| density | 1.0040 (rough estimate) |
| refractive index | 1.4840 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 15.10±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,4622 |
| CAS DataBase Reference | 467-55-0(CAS DataBase Reference) |
Safety Information
Hecogenin Usage And Synthesis
| Uses | antiinflammatory |
| Uses | Hecogenin, is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties. |
| Definition | ChEBI: Hecogenin is a triterpenoid. |
| in vivo | Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1]. | Animal Model: | Male Swiss mice (20-30 g) with ethanol[1] | | Dosage: | 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg | | Administration: | Oral administration; for 15 hours | | Result: | Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa. |
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| Purification Methods | The saponin (~35 mg) in EtOAc is chromatographed on Al2O3 and eluted with *C6H6/Et2O, and the residue on evaporation is recrystallised from Me2CO. [Mazur et al. J Am Chem Soc 82 5889 1960, Marker et al. J Am Chem Soc 69 2167 1947, Beilstein 19 III/IV 2581.] |
Hecogenin Preparation Products And Raw materials
| Preparation Products | 3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate-->16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate-->16,17-Epoxy-16-methyl pregn-9(11)-en-3-ol-20-one-->3-Acetyloxy-16-methylpregna-9(11),16-dien-20-one-->Oxymetholone-->17-methyl-5alpha-androstane-3beta,17beta-diol-->(3,5,25R)-3-Hydroxyspirost-9(11)-ene-->Dexamethasone 9,11-epoxide |
