Introduction：Basic information about helichrysetin CAS 62014-87-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
helichrysetin Basic information
| Product Name: | helichrysetin |
| Synonyms: | helichrysetin;1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-(4-hydroxy-phenyl)-propenone;(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-;(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;Heliocentric;Inhibitor,Apoptosis,growth,DCIS,Helichrysetin,inhibit,cell,cycle,ID2,anticancer;2',4,4'-Trihydroxy 6'-methoxychalcone |
| CAS: | 62014-87-3 |
| MF: | C16H14O5 |
| MW: | 286.28 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 62014-87-3.mol |
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helichrysetin Chemical Properties
| Melting point | 220 °C (decomp) |
| Boiling point | 532.0±50.0 °C(Predicted) |
| density | 1.369±0.06 g/cm3(Predicted) |
| storage temp. | -20°C, protect from light |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| pka | 7.08±0.40(Predicted) |
| color | Yellow |
| InChI | 1S/C16H14O5/c1-21-15-9-12(18)8-14(20)16(15)13(19)7-4-10-2-5-11(17)6-3-10/h2-9,17-18,20H,1H3/b7-4+ |
| InChIKey | OWGUBYRKZATRIT-QPJJXVBHSA-N |
| SMILES | O(C)c1c(c(cc(c1)O)O)C(=O)\C=C\c2ccc(cc2)O |
| LogP | 3.080 (est) |
Safety Information
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
helichrysetin Usage And Synthesis
| Uses | Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity[1][2][3]. |
| Definition | ChEBI: Helichrysetin is a member of chalcones. |
| in vivo | Helichrysetin (10 mg/kg, Intraperitoneal injection) can inhibit DCIS growth in mice with no obvious side effects[1].
Helichrysetin (3, 10, 30 mg/kg, Intraperitoneal injection) can inhibit tumor growth in a mouse model of gastric cancer cell transplantation[3].
| Animal Model: | MGC803 cell-xenografted mouse model[3] | | Dosage: | 3, 10, 30 mg/kg | | Administration: | i.p. | | Result: | Decreased the tumor size and weight without an obvious effect on body weight in nude mice.Reduced the expression of Ki67 and increased the number of apoptotic cells in tumor tissues. |
|
| target | HIV |
| References | [1] Liu Y, et al. ID2 and GJB2 promote early-stage breast cancer progression by regulating cancer stemness. Breast Cancer Res Treat. 2019 May;175(1):77-90. DOI:10.1007/s10549-018-05126-3
[2] Ho YF, et al. Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells. Evid Based Complement Alternat Med. 2013;2013:857257. DOI:10.1155/2013/857257
[3] Wang P, et al. Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming. Acta Pharmacol Sin. 2022 Jun;43(6):1581-1593. DOI:10.1038/s41401-021-00750-0 |
helichrysetin Preparation Products And Raw materials
