HEMATOPORPHYRIN DIHYDROCHLORIDE CAS 17696-69-4
Introduction：Basic information about HEMATOPORPHYRIN DIHYDROCHLORIDE CAS 17696-69-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
HEMATOPORPHYRIN DIHYDROCHLORIDE Basic information
| Product Name: | HEMATOPORPHYRIN DIHYDROCHLORIDE |
| Synonyms: | 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;ematoporfirina;HEMATOPORPHYRIN IX DIHYDROCHLORIDE;HEMATOPORPHYRIN DIHYDROCHLORIDE;HAEMATOPORPHYRIN DIHYDROCHLORIDE |
| CAS: | 17696-69-4 |
| MF: | C34H39ClN4O6 |
| MW: | 635.16 |
| EINECS: | 241-699-4 |
| Product Categories: | Natural Porphyrins and Derivitives;Porphyrins;Biochemistry;Miscellaneous Biochemicals;porphine (porphyrin) ligand |
| Mol File: | 17696-69-4.mol |
HEMATOPORPHYRIN DIHYDROCHLORIDE Chemical Properties
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Very Dark Red |
| Water Solubility | Insoluble in water. Soluble in pyridine (5%). |
| Merck | 14,4636 |
| BRN | 78957 |
| Stability: | Hygroscopic |
| EPA Substance Registry System | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
Safety Information
| Risk Statements | 33 |
| RTECS | TS5505000 |
| TSCA | TSCA listed |
| Toxicity | mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978. |
| Description | Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM. Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation. |
| Uses | Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate. |
| References | [1] KESSEL D. Hematoporphyrin and HPD: photophysics, photochemistry and phototherapy.[J]. Photochemistry and Photobiology, 1984, 39 6: 851-859. DOI: 10.1111/j.1751-1097.1984.tb08871.x [2] C SALET G M. Photodynamic effects of haematoporphyrin on respiration and calcium uptake in isolated mitochondria.[J]. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1981, 39 2: 227-230. DOI: 10.1080/09553008114550261 [3] M. EGYEKI . DNA damaging capability of hematoporphyrin towards DNAs of various accessibilities[J]. Journal of photochemistry and photobiology. B, Biology, 2006, 84 2: Pages 119-127. DOI: 10.1016/j.jphotobiol.2006.02.005 [4] L TOMIO. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats.[J]. Acta radiologica. Oncology, 1983, 22 1: 49-53. DOI: 10.3109/02841868309134338 |
HEMATOPORPHYRIN DIHYDROCHLORIDE Preparation Products And Raw materials
