Introduction：Basic information about HigenaMine Hydrochloride CAS 11041-94-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
HigenaMine Hydrochloride Basic informationToxicity
| Product Name: | HigenaMine Hydrochloride |
| Synonyms: | Demethyl;1,2,3,4-Tetrahydro-1-((4-hydroxyphenyl)methyl)-6,7-isoquinolinediol hydrochloride;Higenamine hydrochloride;Dacacine base acid and alkali salt;6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline;6,7-Dihydroxy-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride;6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1);1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrochloride |
| CAS: | 11041-94-4 |
| MF: | C16H18ClNO3 |
| MW: | 307.77 |
| EINECS: | 1592732-453-0 |
| Product Categories: | 11041-94-4 |
| Mol File: | 11041-94-4.mol |
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HigenaMine Hydrochloride Chemical Properties
| storage temp. | 4°C, protect from light |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Beige to Pale Brown |
| Stability: | Hygroscopic |
Safety Information
| Toxicity | mouse,LD50,intravenous,17250ug/kg (17.25mg/kg),Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 489, 1982. |
HigenaMine Hydrochloride Usage And Synthesis
| Toxicity | The safety of orally administered higenamine hydrochloride in humans is unknown. During a study of acute toxicity, mice were orally administered the compound at a dose of 2 g per kg of bodyweight. No mice died during the study.In human trials of intravenous higenamine, subjects who received higenamine reported shortness of breath, racing heart, dizziness, headaches, chest tightness. |
| Description | Higenamine is a chemical found in several plants including aconite, Annona squamosa, Nandina domestica (sacred bamboo), and others. HigenaMine Hydrochloride is the hydrochloride form of higenamine. |
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata. |
| Uses | Higenamine HCl (norcoclaurine) is a plant-based alkaloid widely used as nutritional supplement in food and beverage industries. |
| in vivo | Higenamine hydrochloride (10 mg/kg; Intraperitoneal injection; Single dose) can significantly reduce the inflammation and infarct size of cerebral ischemic injury caused by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats[2].
Higenamine hydrochloride (0.5-4.5 mg/kg; Single dose) improves cardiac and renal function in rats with cardio-renal syndrome (CRS) and alleviates cardiac and renal fibrosis by targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway in Sprague-Dawley rats[4].
Higenamine hydrochloride (20 mg/kg-30 mg/kg; Intraperitoneal injection; Once daily for 60 days) promotes bone formation and prevents accelerated bone loss in SAMP6 mice[6].
| Animal Model: | Spontaneous osteoporosis SAMP6 mice model[6] | | Dosage: | 10 mg/kg, 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.);Once daily for 60 days | | Result: | Significantly increased the expression of P1NP and OCN (P1NP and OCN are markers of bone formation). |
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| IC 50 | β adrenergic receptor; ASK1 |
HigenaMine Hydrochloride Preparation Products And Raw materials
| Raw materials | 4-Benzyloxyphenylacetonitrile-->TRANS-3 4-BENZYLOXY-TRANS-B-NITROSTYREN&-->4-BENZYLOXYPHENYLACETYL CHLORIDE-->3,4-Dibenzyloxyphenethylamine hydrochloride-->4-BENZYLOXYPHENYLACETIC ACID |
