Introduction：Basic information about HISPIDULIN CAS 1447-88-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
HISPIDULIN Basic information
| Product Name: | HISPIDULIN |
| Synonyms: | SCUTELLAREIN 6-METHYL ETHER;4',5,7-Trihydroxy-6-methoxyflavone;5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;6-Methoxyapigenin;6-Methylscutellarein;Hispidulin(Dinatin);Methoxyapigenin;Dinatin |
| CAS: | 1447-88-7 |
| MF: | C16H12O6 |
| MW: | 300.26 |
| EINECS: | |
| Product Categories: | Miscellaneous Natural Products |
| Mol File: | 1447-88-7.mol |
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HISPIDULIN Chemical Properties
| Melting point | 291-292 °C |
| Boiling point | 601.5±55.0 °C(Predicted) |
| density | 1.512±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 6.51±0.40(Predicted) |
| form | powder |
| color | white to beige |
| InChI | InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3 |
| InChIKey | IHFBPDAQLQOCBX-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1 |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| RTECS | DJ2996000 |
| Storage Class | 11 - Combustible Solids |
HISPIDULIN Usage And Synthesis
| Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the lychee grass extracted from the inside of the Asteraceae plant ragweed whole grass, snow lotus. |
| Uses | Hispidulin has been used as a calibration standard:
- in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
- in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
- in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
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| Definition | ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6. |
| General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG |
| Biological Activity | Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties. |
| Biochem/physiol Actions | Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand. |
HISPIDULIN Preparation Products And Raw materials
| Preparation Products | cirsimaritin |
