HYOSCYAMINE SULFATE CAS 620-61-1

Introduction：Basic information about HYOSCYAMINE SULFATE CAS 620-61-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

HYOSCYAMINE SULFATE Basic information

• Product Name: HYOSCYAMINE SULFATE
• Synonyms: [3(s)-endo]-lestesulfate(2:1)(salt);1-alpha-h,5-alpha-h-tropan-3-alpha-ol,(-)-tropate(ester),sulfate(2:1);egazil;levsinsulfate;L-HYOSCYAMINE SULFATE;L-HYOSCYAMINE SULFATE HEMISULFATE SALT;L-TROPINE TROPATE SULFATE;(-)-HYOSCYAMINE SULFATE
• CAS: 620-61-1
• MF: C34H48N2O10S
• MW: 676.82
• EINECS: 210-644-6
• Product Categories: Tropane Alkaloids;Alkaloids;Biochemistry
• Mol File: 620-61-1.mol

HYOSCYAMINE SULFATE Chemical Properties

• Melting point: 205-206℃
• refractive index: -28 ° (C=5, H2O)
• storage temp.: Store at -20°C
• solubility: Soluble in DMSO
• form: Solid
• color: White to off-white
• Merck: 4858
• CAS DataBase Reference: 620-61-1(CAS DataBase Reference)
• EPA Substance Registry System: Benzeneacetic acid, .alpha.-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(S)-endo]-, sulfate (2:1) (salt) (620-61-1)

Safety Information

• Risk Statements: 26/28
• Safety Statements: 1-24/25-45
• RTECS: YM6107000
• TSCA: TSCA listed

HYOSCYAMINE SULFATE Usage And Synthesis

Uses

L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205)[1][2].

General Description

Hyoscyamine sulfate(Levsin sulfate) is a white, odorless, crystalline compoundof a deliquescent nature that also is affected by light. It issoluble in water (1:0.5) and alcohol (1:5) but almost insolublein ether. Solutions of hyoscyamine sulfate are acidicto litmus.

Clinical Use

Hyoscyamine sulfate is used as an anticholinergic in the same mannerand for the same indications as atropine and hyoscyamine, butit possesses the disadvantage of being deliquescent.

in vivo

L-Hyoscyamine sulfate (Daturine sulfate; 5-20 mg/kg; iv) prolongs the migrating MMC cycle length^[1].

• Animal Model: Rats^[1]
• Dosage: 5, 10, 20 mg/kg
• Administration: IV
• Result: Prolonged the migrating myoelectric complex (MMC) cycle length.

References

[1] Lars G?ran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. DOI:10.1016/s0014-2999(03)01637-6
[2] Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4(3-4):194-8. DOI:10.1002/dta.338