HYPOCRELLIN A CAS 77029-83-5

Introduction：Basic information about HYPOCRELLIN A CAS 77029-83-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

HYPOCRELLIN A Basic information

• Product Name: HYPOCRELLIN A
• Synonyms: HYPOCRELLIN;HYPOCRELLIN A;1H-Cyclohepta[ghi]perylene-5,12-dione,1-acetyl-2,3-dihydro-2,6,11-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-,stereoisomer;(1S,2R)-1-acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-2,3-dihydro-1H-cyclohepta[ghi]perylene-6,11-dione;(11R,12S)-11-acetyl-3,9,12-trihydroxy-1,5,6,10-tetramethoxy-12-methyl-12,13-dihydro-2H-cyclohepta[ghi]perylene-2,8(11H)-dione;(1S,2R)-1-acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-m...;11-epoxide;Dexamethasone 9
• CAS: 77029-83-5
• MF: C30H26O10
• MW: 546.52
• Mol File: 77029-83-5.mol

HYPOCRELLIN A Chemical Properties

• Melting point: 209-210 °C
• Boiling point: 922.8±65.0 °C(Predicted)
• density: 1.55±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMF: 2mg/mL; DMSO: 3mg/mL; Ethanol: 0.3mg/mL
• form: A solid
• pka: 7.03±0.60(Predicted)
• color: Brown to red
• InChIKey: URTOHKHBNYPGQJ-UHYDGBJBNA-N
• SMILES: C12C3[C@@H](C(=O)C)[C@](O)(C)CC4=C(C(=O)C5=C(C=C(OC)C(C6C(OC)=CC(=O)C(=C(O)C=3OC)C1=6)=C5C=24)O)OC |&1:2,6,r|

HYPOCRELLIN A Usage And Synthesis

Chemical Properties

Red crystal, odorless, tasteless, purity 98%, melting point 209-210 ℃, soluble in chloroform, acetone, ethyl acetate, soluble in methanol, ethanol, slightly soluble in petroleum ether, insoluble in water, not easy to hydrolysis, but in the alkaline environment can be self-sensitive photo-oxidation of photolysis; now the folk used as a drug to treat gastric pain and arthritis and is the treatment of dermatological disorders, anti-tumor, anti-AIDS, the potentially effective It is also a potentially effective photosensitive drug for the treatment of skin diseases, anti-tumor and anti-AIDS.

Uses

Hypocrellin A is an antimicrobial and antileishmanial activity. Ga(3+)-Hypocrellin interacts with myoglobin in vitro.

in vivo

Hypocrellin A (2.5 and 5 mg/kg; i.p.; once every two days for fourteen days) inhibits tumor growth in a non-small cell lung cancer xenograft model mouse model^[8].

• Animal Model: H460 cells were inoculated subcutaneously on the backs of BALB/c nude mice^[8]
• Dosage: 2.5 and 5 mg/kg
• Administration: i.p.; Inject once every two days for fourteen days
• Result: Induced the expression of the pro-apoptotic protein BAX and inhibited the expression of the anti-apoptotic protein BCL-2 in NSCLC tumors.

IC 50

Leishmania