isodiospyrin CAS 20175-84-2

Introduction：Basic information about isodiospyrin CAS 20175-84-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

isodiospyrin Basic information

• Product Name: isodiospyrin
• Synonyms: isodiospyrin;[1,2’-Binaphtalene]-5,5’,8,8’-tet;1,2’-Binaphthalene-5,5’,8,8’-tet;[1,2'-BINAPHTHALENE]-5,5',8,8';Isoquinone;(-)-1',4-Dihydroxy-2,3'-dimethyl-(1,2'-binaphthalene)-5,5',8,8'-tetrone;Isodiospirin;[1,2'-Binaphthalene]-5,5',8,8'-tetrone,1',4-dihydroxy-2,3'-dimethyl-, (1R)-
• CAS: 20175-84-2
• MF: C22H14O6
• MW: 374.34
• Mol File: 20175-84-2.mol

isodiospyrin Chemical Properties

• Melting point: 233 °C
• Boiling point: 712.0±60.0 °C(Predicted)
• density: 1.495±0.06 g/cm3(Predicted)
• pka: 5.66±0.20(Predicted)
• form: Solid
• color: Orange to red

isodiospyrin Usage And Synthesis

Uses

Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3].

Definition

ChEBI: Isodiospyrin is a member of biphenyls.

IC 50

Topoisomerase I

References

[1] Chun-Yuan Ting, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 2003 Nov 15;66(10):1981-91. DOI:10.1016/j.bcp.2003.07.003
[2] B A Adeniyi, et al. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae). Phytother Res. 2000 Mar;14(2):112-7. DOI:3.0.co;2-t">10.1002/(sici)1099-1573(200003)14:2<112::aid-ptr488>3.0.co;2-t
[3] Xiaoning Wang, et al. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chem Biodivers. 2011 Dec;8(12):2331-40. DOI:10.1002/cbdv.201000310