Isojacareubin CAS 50597-93-8

Introduction：Basic information about Isojacareubin CAS 50597-93-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Isojacareubin Basic information

• Product Name: Isojacareubin
• Synonyms: Isojacareubin;3H,7H-Pyrano[2,3-c]xanthen-7-one, 6,10,11-trihydroxy-3,3-dimethyl-;6,10,11-Trihydroxy-3,3-dimethylpyrano[2,3-c]xanthen-7(3H)-one
• CAS: 50597-93-8
• MF: C18H14O6
• MW: 326.3
• Mol File: 50597-93-8.mol

Isojacareubin Chemical Properties

• form: Solid
• color: Light yellow to yellow

Isojacareubin Usage And Synthesis

Uses

Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis[1][2][3].

References

[1] Kyoko Ishiguro, et al. An isopentenylated flavonol from Hypericum japonicum. Phytochemistry. 1993. 32 (6), 1583-1585.
[2] Khan A, et al. Discovery of Isojacareubin as a covalent inhibitor of SARS-CoV-2 main protease using structural and experimental approaches. J Med Virol. 2023 Feb;95(2):e28542. DOI:10.1002/jmv.28542
[3] Yuan X, et al. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo. Sci Rep. 2015 Aug 6;5:12889. DOI:10.1038/srep12889