Introduction：Basic information about J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone CAS 16265-56-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Table of Contents
- 1. J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Basic information
- 2. J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Chemical Properties
- 3. Safety Information
- 4. J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Usage And Synthesis
- 5. J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Preparation Products And Raw materials
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Basic information
| Product Name: | J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone |
| Synonyms: | 5,10-Dihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one;6-Deoxyjacareubin;9-Deshydroxyjacareubin;J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone;6-Dehydroxyjacareubin;6-Desoxyjacareubin;2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,10-dihydroxy-2,2-dimethyl-;5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one |
| CAS: | 16265-56-8 |
| MF: | C18H14O5 |
| MW: | 310.3 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 16265-56-8.mol |
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J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Chemical Properties
| Melting point | 214-215℃ |
| Boiling point | 523.4±50.0 °C(Predicted) |
| density | 1.410±0.06 g/cm3(Predicted) |
| pka | 6.59±0.40(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Safety Information
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Usage And Synthesis
| Uses | 6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1]. |
| Definition | ChEBI: 6-Deoxyjacareubin is a member of pyranoxanthones. |
| in vivo | 6-Deoxyjacareubin (5 mg/kg, i.p., every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1]. | Animal Model: | Male SOD1G93A mice (eight weeks)[1] | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneally (i.p.), every seven days for 1 month | | Result: | Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss. |
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| References | [1] Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51. DOI:10.1016/j.neures.2020.02.011 |
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone Preparation Products And Raw materials
