Introduction：Basic information about Jaceosidin CAS 18085-97-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Jaceosidin Basic information
| Product Name: | Jaceosidin |
| Synonyms: | JACEOSIDIN;3',6-Dimethoxy-4',5,7-trihydroxyflavone;5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;6-Hydroxyluteolin 3',6-dimethyl ether;Jacesiolin;4',5,7-Trihydroxy-3',6-dimethoxyflavone;4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-;5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one |
| CAS: | 18085-97-7 |
| MF: | C17H14O7 |
| MW: | 330.29 |
| EINECS: | |
| Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 18085-97-7.mol |
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Jaceosidin Chemical Properties
| Melting point | 259-260 °C |
| Boiling point | 619.0±55.0 °C(Predicted) |
| density | 1.483±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly) |
| form | Solid |
| pka | 6.47±0.40(Predicted) |
| color | Pale Yellow to Light Yellow |
| Stability: | Hygroscopic |
| Major Application | food and beverages |
| InChI | InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3 |
| InChIKey | GLAAQZFBFGEBPS-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C(OC)=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1 |
| LogP | 1.300 (est) |
Safety Information
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
Jaceosidin Usage And Synthesis
| Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the leaves of Ailanthus, long-leaved arnica flowers, silver artemisia above ground, stevia, the leaves of the ground yellow, the above ground parts of the vine. |
| Uses | Jaceosidin exhibits anti-allergic, anti-inflammatory and apoptosis inducing activities. |
| Definition | ChEBI: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apotosis inducing activties. |
| in vivo | Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice[3].
?Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice[3].
?Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats[3]. | Animal Model: | 5-week-old male BALB/c mice (23-26 g)[3] | | Dosage: | 10 and 20 mg/kg | | Administration: | P.O. once a day for 3 days | | Result: | Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation.| Animal Model: | Male Sprague-Dawley rats (180-200 g)[3] | | Dosage: | 20 mg/kg | | Administration: | P.O., for 2 hour | | Result: | Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively. |
| | IC 50 | Bax; COX-2 |
Jaceosidin Preparation Products And Raw materials |
