Keverprazan Hydrochloride CAS 2209911-80-6

Introduction：Basic information about Keverprazan Hydrochloride CAS 2209911-80-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Keverprazan Hydrochloride Basic information

• Product Name: Keverprazan Hydrochloride
• Synonyms: 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1);P-CAB agent 2 hydrochloride;1-(5-(2-Fluorophenyl)-1-((3-(3-methoxypropoxy)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine hydrochloride;Carenoprazan HCl
• CAS: 2209911-80-6
• MF: C22H26ClFN2O4S
• MW: 468.97
• Mol File: 2209911-80-6.mol

Keverprazan Hydrochloride Chemical Properties

• form: Solid
• color: Off-white to light yellow

Keverprazan Hydrochloride Usage And Synthesis

Uses

P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].

in vivo

P-CAB agent 2 hydrochloride (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats^[1].
P-CAB agent 2 hydrochloride (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats^[1].

• Animal Model: 180-220 g, SPF grade, male SD rats^[1]
• Dosage: 2 mg/kg
• Administration: P.o.; once
• Result: Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.

References

[1] YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.