Introduction：Basic information about L-DIHYDROOROTIC ACID CAS 5988-19-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-DIHYDROOROTIC ACID Basic information
| Product Name: | L-DIHYDROOROTIC ACID |
| Synonyms: | L-DIHYDROOROTIC ACID;L-HYDROOROTIC ACID;DIHYDRO-L-OROTIC ACID;(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid;(S)-(+)-HYDROOROTIC ACID;(4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid |
| CAS: | 5988-19-2 |
| MF: | C5H6N2O4 |
| MW: | 158.11 |
| EINECS: | 624-952-7 |
| Product Categories: | Heterocycles;Miscellaneous Biochemicals;Amino Acid Derivatives;5988-19-2 |
| Mol File: | 5988-19-2.mol |
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L-DIHYDROOROTIC ACID Chemical Properties
| Melting point | 254-255 °C (dec.)(lit.) |
| Boiling point | 283.16°C (rough estimate) |
| density | 1.523 |
| refractive index | 1.5090 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) |
| pka | 2.82±0.20(Predicted) |
| form | Powder |
| color | White to off-white |
| Water Solubility | Soluble in water (partly), and dimethyl formamide. |
| InChI | InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1 |
| InChIKey | UFIVEPVSAGBUSI-REOHCLBHSA-N |
| SMILES | C1(=O)NC(=O)C[C@@H](C(O)=O)N1 |
| CAS DataBase Reference | 5988-19-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Orotic acid, dihydro-, l-(5988-19-2) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
L-DIHYDROOROTIC ACID Usage And Synthesis
| Chemical Properties | White to off-white crystalline powder |
| Uses | L-Dihydroorotic acid a metabolite. |
| Definition | ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid. |
| Biochem/physiol Actions | L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors. |
| IC 50 | Microbial Metabolite; Human Endogenous Metabolite |
L-DIHYDROOROTIC ACID Preparation Products And Raw materials
| Raw materials | Orotic acid |
| Preparation Products | Disodium 5'-Inosinate-->Ribavirin-->CALCIUM5'-RIBONUCLEOTIDES-->Idoxuridine |
