Introduction：Basic information about Lercanidipine CAS 100427-26-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Lercanidipine Basic information
| Product Name: | Lercanidipine |
| Synonyms: | LERCANIDIPINE;1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITTROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-[(3,3-DIPHENYLPROPYL)METHYLAMINO]-1,1-DIMETHYLETHYL METHYL ESTER;methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;LercanidipineC36H41N306;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl]5-methyl ester;2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[1,1-dimethyl-2-[methyl(3,3-diphenylpropyl)amino]ethyl] ester;Masnidipine |
| CAS: | 100427-26-7 |
| MF: | C36H41N3O6 |
| MW: | 611.73 |
| EINECS: | 807-432-6 |
| Product Categories: | Inhibitors;inhibitor |
| Mol File: | 100427-26-7.mol |
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Lercanidipine Chemical Properties
| Melting point | 118-120°C |
| Boiling point | 712.5±60.0 °C(Predicted) |
| density | 1.177±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 8.66±0.50(Predicted) |
| color | Light yellow to yellow |
| CAS DataBase Reference | 100427-26-7(CAS DataBase Reference) |
Safety Information
Lercanidipine Usage And Synthesis
| Description | Lerdip was launched in the Netherlands for hypertension. It is prepared infour steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]-2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl3-aminocrotonate. This compound was designed to be very lipophilic which impartsthe drug with a gradual onset and a long duration of action as a result of prolongedexposure to receptors by partitioning into membranes. It is an antagonist of L-typecalcium channels with no activity in smooth muscle cells, is tissue selective, lacks anymyocardial contractility impairment, has no neuroendocrine activation, and hasnegligible affinity for neurotransmitter receptors such as α1- and α2-adrenergicreceptors. While sold as a racemate, the calcium channel activity is found in the (S)-isomer with the (R)-isomer being 2-orders of magnitude less active. It has anincreased cardiac contractility index which is much more than Nitrendipine ornifedipine. The good selectivity causes a reduction in blood pressure with no negativeinotropic effects. |
| Originator | Recordati (Italy) |
| Uses | Antihypertensive compound; calcium channel blocker. |
| Definition | ChEBI: Lercanidipine is a diarylmethane. |
| Brand name | Cardiovasc (Recor dati, Italy); Carmen (Recordati, Italy); Corifeo (Recordati,Italy); Lercadip (Recordati, Italy); Lercan (Recordati,Italy); Lercapin (Recordati, Italy); Lercaton (Recordati,Italy); Lerkamen (Recordati, Italy); Lerzam (Recordati,Italy); Renovia (Recordati, Italy); Vasodip (Recordati,Italy); Zandip (Recordati, Italy); Zanicor (Recordati, Italy). |
Lercanidipine Preparation Products And Raw materials
| Preparation Products | Lercanidipine hydrochloride |
