CAS 132866-11-6|Lercanidipine hydrochloride

Introduction：Basic information about CAS 132866-11-6|Lercanidipine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Lercanidipine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles27
6. Synonyms

Common Name	Lercanidipine hydrochloride
CAS Number	132866-11-6	Molecular Weight	648.188
Density	/	Boiling Point	712.5ºC at 760mmHg
Molecular Formula	C₃₆H₄₂ClN₃O₆	Melting Point	175-177ºC
MSDS	ChineseUSA	Flash Point	384.7ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	Lercanidipine Hydrochloride
Synonym	More Synonyms

Lercanidipine hydrochloride BiologicalActivity

Description	Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease
References	[1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70. [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

Description

Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease

References

[1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70.

[2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

Chemical & Physical Properties

Boiling Point	712.5ºC at 760mmHg
Melting Point	175-177ºC
Molecular Formula	C₃₆H₄₂ClN₃O₆
Molecular Weight	648.188
Flash Point	384.7ºC
Exact Mass	647.276184
PSA	113.69000
LogP	8.13240
Vapour Pressure	3.77E-20mmHg at 25°C
InChIKey	WMFYOYKPJLRMJI-UHFFFAOYSA-N
SMILES	COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1.Cl
Storage condition	2-8°C

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	S36/37-S45
RIDADR	UN 2811

Articles27

Differences in lercanidipine systemic exposure when administered according to labelling: in fasting state and 15 minutes before food intake.

Eur. J. Clin. Pharmacol. 68(7) , 1043-7, (2012)

The aim of this study was to compare the systemic exposure of lercanidipine (Zanidip) after oral administration in the fasted state and 15 min before food intake (meals) to investigate if the recommen...

Rationale for the use of a fixed-dose combination in the management of hypertension: efficacy and tolerability of lercanidipine/enalapril.

Clin. Drug Investig. 30(12) , 843-54, (2010)

Hypertension, a significant factor in the development of cerebrovascular disorders, heart disease and renal failure, is a common disorder worldwide. Despite the availability of a wide range of antihyp...

Lercanidipine rescues hippocampus pyramidal neurons from mild ischemia-induced delayed neuronal death in SHRSP.

Cell. Mol. Neurobiol. 31(4) , 561-7, (2011)

Stroke-prone spontaneously hypertensive rats (SHRSPs) are vulnerable to ischemia and delayed neuronal death (DND) of hippocampus pyramidal cells when bilateral carotid arteries are occluded for only 1...

Synonyms

Renovia

Vasodip

Carmen

Lercadip

Lercan

Lercaton

2-((3,3-diphenylpropyl)methylamino)-1,1-dimethylethyl methyl (4RS)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate monohydrochloride

Lercapin

Lerdip

Cardiovasc

Lercanidipine hydrochloride

Corifeo

Lercanidipine hydrochloride hemihydrate

Lerkamen

Zanicor

1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)

Masnidipine hydrochloride

REC 15-2375

1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)

Lerzam

MFCD07773089

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester, hydrochloride (1:1)

Zandip

Zanidip

Lercanidipine (hydrochloride)

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