Introduction：Basic information about Loxoprofen CAS 68767-14-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Loxoprofen Basic information
| Product Name: | Loxoprofen |
| Synonyms: | IOXOPROFEN;2-[4-[(2-Oxocyclopentan-1-yl)methyl]phenyl]propionic acid;KOLOXO;LOXOPROFEN;2-[4-(2-OXO-CYCLOPENTYLMETHYL)-PHENYL]-PROPIONIC ACID;A-METHYL-4-[(2-OXOCYCLOPENTYL)METHYL]BENZENEACETIC ACID;α-methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid;2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid |
| CAS: | 68767-14-6 |
| MF: | C15H18O3 |
| MW: | 246.31 |
| EINECS: | 1806241-263-5 |
| Product Categories: | LOXONIN;Active Pharmaceutical Ingredients |
| Mol File: | 68767-14-6.mol |
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Loxoprofen Chemical Properties
| Melting point | 108.5-111° |
| Boiling point | bp0.3 190-195° |
| density | 1.182±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 4.39±0.10(Predicted) |
| form | solid |
| color | White to Off-White |
| Merck | 14,5589 |
| InChI | InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18) |
| InChIKey | YMBXTVYHTMGZDW-UHFFFAOYSA-N |
| SMILES | C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1 |
| CAS DataBase Reference | 68767-14-6(CAS DataBase Reference) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2918.99.3000 |
| Storage Class | 11 - Combustible Solids |
Loxoprofen Usage And Synthesis
| Uses | antiinflammatory, analgesic |
| Uses | Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase. |
| Definition | ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted to its active trans-alcohol metabolite following ora administration. |
| Synthesis | Ethyl 2-oxocyclopentanecarboxylate and potassium hydroxide in dimethylformamide were reacted with ethyl 2-(4-chloro-phenyl)propionate at 80 ??C for 2 h. The product obtained was reacted with 47% hydrobromic acid and hydrolyzed and decarboxylated to give loxoprofen. |
Loxoprofen Preparation Products And Raw materials
| Raw materials | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester-->Cyclopentanecarboxylic acid-->ETHYL PHENYLPROPIOLATE |
