Introduction：Basic information about L-Ribose CAS 24259-59-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Ribose Basic information
| Product Name: | L-Ribose |
| Synonyms: | (2S,3S,4S)-2,3,4,5-Tetrahydroxypentanal;L-Ribose ,98%;L-(+)-Ribos;(2R,3S,4R,5S)-5-(hydroxymethyl)oxolane-2,3,4-triol;L-D-Ribose;l-[1-13C]ribose;l-[UL-13C5]ribose;aldehydo-L-ribose |
| CAS: | 24259-59-4 |
| MF: | C5H10O5 |
| MW: | 150.13 |
| EINECS: | 246-110-4 |
| Product Categories: | Monosaccharides;MonosaccharideSpecialty Synthesis;Carbohydrate Synthesis;Carbohydrates;Carbohydrates A to;Carbohydrates P-ZBiochemicals and Reagents;13C & 2H Sugars;Basic Sugars (Mono & Oligosaccharides);Biochemistry;Nucleosides, Nucleotides & Related Reagents;Ribose;Riboses and 2'-Deoxyriboses;Sugars;Carbohydrates & Derivatives;CARBOHYDRATE;Sugars, Carbohydrates & Glucosides;bc0001;24259-59-4;Glycon Biochem |
| Mol File: | 24259-59-4.mol |
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L-Ribose Chemical Properties
| Melting point | 81-82 °C(lit.) |
| alpha | 20 º (c=2,water) |
| Boiling point | 191.65°C (rough estimate) |
| density | 1.1897 (rough estimate) |
| refractive index | 20 ° (C=1, H2O) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 12.22(at 25℃) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water (100 mg/ml). |
| BRN | 1723084 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5-/m1/s1 |
| InChIKey | PYMYPHUHKUWMLA-MROZADKFSA-N |
| SMILES | O=C[C@H]([C@H]([C@H](CO)O)O)O |
| CAS DataBase Reference | 24259-59-4(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-37-36-36/38 |
| Safety Statements | 24/25-36-26-37/39 |
| WGK Germany | 3 |
| RTECS | 246-110-4 |
| F | 3-10 |
| HS Code | 29400000 |
| Storage Class | 11 - Combustible Solids |
L-Ribose Usage And Synthesis
| Chemical Properties | white crystals or powder |
| Uses | It is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate. |
| Uses | L-[1-13C]ribose is a compound useful in organic synthesis. |
| Definition | A monosaccharide; a component of RNA. |
| Definition | ribose: A monosaccharide, C5H10O5, rarely occurring free in nature but important as a component of RNA (ribonucleic acid). Its derivative deoxyribose, C5H10O4, is equally important as a constituent of DNA (deoxyribonucleic acid), which carries the genetic code in chromosomes. |
| Biosynthesis | L-ribose is the enantiomer of D-ribose, which occurs naturally. It is a building block of many novel nucleotide analogue anti-viral drugs. Bio-production of L-ribose relies on a two-step reaction: (i) conversion of L-arabinose to L-ribulose by the catalytic action of L-arabinose isomerase (L-AI) and (ii) conversion of L-ribulose to L-ribose by the catalytic action of L-ribose isomerase (L-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Among the two enzymes, L-RI is a rare enzyme discovered in 1996 by Professor Izumori's group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms[1]. |
| Synthesis | A method for converting inexpensive, naturally occurring D-ribose into L-ribose is by interconverting the hydroxy group at Cl and the hydroxymethyl group at C5. L-Ribose is prepared from D-ribose by (a) forming a hydroxy-protected D-ribose, (b) reducing the hydroxy-protected D-ribose to a protected tetrol, (c) converting the tetrol to a tetraester, such as a tetraacetate; (d) hydrolyzing the protecting group to form a hydroxymethyl tetraester; (e) oxidizing the hydroxymethyl group to form a tetraester aldehyde; and (f) hydrolysing the ester groups to yield L-ribose. |
| References | [1] M. Helanto. “Biotechnological production of l-ribose from l-arabinose.” Applied Microbiology and Biotechnology 83 1 (2009): 77–83. |
L-Ribose Preparation Products And Raw materials
| Preparation Products | L-erythro-2-Pentulose (9CI)-->β-L-Ribofuranoside, methyl 2,3-O-(1-methylethylidene)- |
