Introduction：Basic information about MANOOL CAS 596-85-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
MANOOL Basic information
| Product Name: | MANOOL |
| Synonyms: | MANOOL;4AR-TRANS-5-(1,5,5,8AS-TETRAMETHYL-2-METHYLENEDECAHYDRO-1-NAPHTHALENYL)-3-R-METHYL-1-PENTEN-3-OL;1-Naphthalenepropanol, alpha-ethenyldecahydro-alpha,5,5,8a-tetramethyl-2-methylene-, [1S-[1alpha(S*),4abeta,8aalpha]]-;5-(5,5,8a-Trimethyl-2-methylenedecahydro-1-naphthalenyl)-3-methyl-1-penten-3-ol;Labda-8(20),14-dien-13-ol, (13R)-;4ARTRANS-5-(-TETRAME-2-METHYLENEDECAHYDR;1-Naphthalenepropanol, .alpha.-ethenyldecahydro-.alpha.,5,5,8a-tetramethyl-2-methylene-, (.alpha.R,1S,4aS,8aS)-;1-Naphthalenepropanol, .alpha.-ethenyldecahydro-.alpha.,5,5,8A-tetramethyl-2-methylene-, [1S-[1.alpha.(S*),4A.beta.,8A.alpha.]]- |
| CAS: | 596-85-0 |
| MF: | C20H34O |
| MW: | 290.48 |
| EINECS: | |
| Product Categories: | Miscellaneous Natural Products |
| Mol File: | 596-85-0.mol |
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MANOOL Chemical Properties
| Melting point | 49-52 °C(lit.) |
| Boiling point | 150-153 °C(Press: 0.3 Torr) |
| density | 0.93±0.1 g/cm3(Predicted) |
| Fp | >230 °F |
| storage temp. | 4°C, stored under nitroge |
| solubility | Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| form | Low-Melting Solid |
| pka | 14.47±0.29(Predicted) |
| color | White to Off-White |
| Specific Gravity | 0.97 |
| Odor | Very delicate, woody, dry-sweet, and extremely tenacious odor |
| LogP | 6.790 (est) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
MANOOL Usage And Synthesis
| Uses | Maintains anti-proliferative activity against human malignant cell strains. |
| Definition | ChEBI: A labdane diterpenoid in which the labdane skeleton has double bonds at positions 8(17) and 14 and carries an R-hydroxy group at position 13. |
| Preparation | By extraction of cornrninuted woodof Dacrydium biforme, a tree indigenous toNew Zealand, with alcohol or Acetone. Theextract is neutralized with alkali, and thecrude Manool may be recrystallized. |
| Cytotoxicity | IC50 (μg/mL): 49.3 (V79), 15.6 (B16F10),17.1 (MCF-7), 6.7 (HeLa), 28.5 (HepG2),9.6 (MO59 J), 6.7 (U343), 13.1 (U251)(de Oliveira et al. 2016) |
MANOOL Preparation Products And Raw materials
| Preparation Products | Sclareol |
