mefruside CAS 7195-27-9

Introduction：Basic information about mefruside CAS 7195-27-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

mefruside Basic information

• Product Name: mefruside
• Synonyms: 1,3-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]- (9CI);4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide;B 1500;BAY 1500;Baycaron;FBA 1500;FDA 1902;m-Benzenedisulfonamide, 4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)- (7CI, 8CI)
• CAS: 7195-27-9
• MF: C13H19ClN2O5S2
• MW: 382.88
• EINECS: 2305624
• Mol File: 7195-27-9.mol

mefruside Chemical Properties

• Melting point: 149.5°C
• Boiling point: 565.2±60.0 °C(Predicted)
• density: 1.3150 (rough estimate)
• refractive index: 1.6100 (estimate)
• storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• pka: 9.26±0.60(Predicted)
• form: Solid
• color: White to Pale Beige
• Stability: Hygroscopic

Safety Information

• Toxicity: LD50 oral in rabbit: > 3gm/kg

mefruside Usage And Synthesis

Originator

Baycaron,Bayer,W. Germany,1967

Uses

Mefruside is a diuretic used for the treatment of edema and hypertension.

Definition

ChEBI: Mefruside is an organic molecular entity.

Manufacturing Process

By hydrogenation of α-methyl-α-cyanotetrahydrofuran with Raney nickel as catalyst, α-methyl-α-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give α-methyl-αtetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol.

Therapeutic Function

Diuretic

mefruside Preparation Products And Raw materials

• Raw materials: Dimethyl sulfate