| Description | Megestrol Acetate is the acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. It is frequently used in the treatment of patients with metastatic breast cancer. It is generally well tolerated, except that it may cause undesirable weight gain. Subsequently, it was shown that megestrol acetate produced weight gain in a variety of cachectic cancer patients. Significant reduction inserum levels of IL-1a and b,IL-2,IL-6, and TNF-o were observed in cancer patientstreated with megestrol acetate which may bear on the mechanism of improved appetite and body weight gain.It has also been postulated that the effect is, at least in part,mediated by NPY,a potent central appetite stimulant. |
| Chemical Properties | Crystalline Solid |
| Originator | Megestat,Bristol,W. Germany,1964 |
| Uses | Megestrol acetate USP (Megace) is used to treat Carcinoma of the breast or endorometrium. |
| Uses | Megestrol acetate (Megace), a semi-synthetic progestational steroid, is the most effective known appetite stimulant at present. Previously used in patients with cancer and acquired immunodeficiency syndrome, only a few studies have considered the applicability of this drug in malnourished older persons.
Megestrol acetate is useful if profound anorexia is the main manifestation of cachexia and if expected survival is weeks to months. Megace has been shown to significantly increase appetite, but not survival. In patients with a shorter predicted survival, a brief course of corticosteroids may be useful to stimulate appetite and have positive effects on nausea, pain, and asthenia. |
| Definition | ChEBI: Megestrol acetate is a steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer. It has a role as an antineoplastic agent, an appetite enhancer, a contraceptive drug, a progestin and a synthetic oral contraceptive. It is a steroid ester, an acetate ester, a 20-oxo steroid and a 3-oxo-Delta(4) steroid. It derives from a megestrol. |
| Manufacturing Process | The following preparation is given in US Patent 3,356,573. 17α-Acetoxy-3βhydroxy-6-methylpregn-5-ene-20-one (1 g), aluminum tert-butoxide (1 g) and p-benzoquinone (6 g) were dissolved in dry benzene (100 ml) and the mixture was heated under reflux for 30 minutes. The reaction mixture was cooled and washed with potassium hydroxide solution until the benzene layer was colorless. The benzene was washed with water, dried and evaporated to dryness under reduced pressure. The residue crystallized from aqueous methanol to give 17α-acetoxy-6-methylpregna-4,6-diene-3,20-dione, needles, MP 214° to 216°C. |
| Brand name | Megace (Bristol-Myers Squibb); Megace (Par). |
| Therapeutic Function | Cancer chemotherapy |
| General Description | Megestrol acetate, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate(Megace), is a progestin used primarily for the palliativemanagement of recurrent, inoperable, or metastatic endometrialor breast carcinoma. Megestrol acetate has also beenindicated for appetite enhancement in patients with AIDS.The biochemical basis for this use of megestrol is unclear. |
| Clinical Use | Progestin activity is further enhanced when a double bond is introduced between positions 6 and 7, as is found in megestrolacetate. Megestrol is used primarily in the treatment of breast and endometrial carcinomas and in postmenopausalwomen with advanced hormone-dependent carcinoma. |
| Safety Profile | Suspected carcinogenwith experimental carcinogenic andteratogenic data. Poison by intravenousroute. Human reproductive effects bpingestion and implant routes: effects onovaries and fallopian tubes, menstrual cyclechanges, and female fertility index changes.Mutation data reported. Experimentalreproductive effects. When heated todecomposition it emits acrid smoke andirritating fumes. An FDA proprietary drugused to treat endometriosis and breastcancer. A steroid. |
| Veterinary Drugs and Treatments | Megestrol acetate (Ovaban?—Schering) is approved by FDA for usein dogs only for the postponement of estrus and the alleviation offalse pregnancy. In male dogs, it has been used for benign prostatichypertrophy. It is used clinically for many dermatologic and behavior-related conditions, primarily in the cat. See the Dosage sectionfor specific indications and dosages for both dogs and cats.
Megestrol acetate is indicated in humans for the palliative treatmentof advanced carcinoma of the breast or endometrium. |
| Metabolism | Less than 10% of an oral dose undergoes metabolism. Several majormetabolites appear in the urine (e.g., 2-hydroxy and 6-hydroxymethyl megestrol and their glucuronide conjugates). |
| storage | Store at RT |
| references | [1] zhang k1, chow pk. the effect of megestrol acetate on growth of hepg2 cells in vitro and in vivo. clin cancer res. 2004 aug 1; 10(15):5226-32. |
