Introduction：Basic information about MELITTIN CAS 20449-79-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
MELITTIN Basic information
| Product Name: | MELITTIN |
| Synonyms: | beevenommelittin;forapin;forapine;Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Gln-L-Gln-NH2;Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Glu(NH2)-L-Glu(NH2)-NH2;GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2;C11198;melittin from honey bee venom |
| CAS: | 20449-79-0 |
| MF: | C131H229N39O31 |
| MW: | 2846.46 |
| EINECS: | 629-303-1 |
| Product Categories: | Amino Acids;Calcium Antagonists;Cell Signaling and Neuroscience;Intracellular Calcium Signaling |
| Mol File: | 20449-79-0.mol |
|
MELITTIN Chemical Properties
| alpha | D21 -89.52° (c = 0.409) |
| density | 1.39 |
| storage temp. | -20°C |
| solubility | Soluble to 1 mg/ml in 20% acetonitrile |
| form | White to faint tan powder. |
| color | White to off-white |
| biological source | animal (Apis mellifera) |
| Water Solubility | Soluble to 1 mg/ml in water |
| Sequence | H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 |
| Cosmetics Ingredients Functions | ANTI-SEBUM |
| InChIKey | VDXZNPDIRNWWCW-JFTDCZMZSA-N |
Safety Information
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36-45-36/37/39 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | OS3965000 |
| F | 10-21 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Oral |
MELITTIN Usage And Synthesis
| Uses | Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions. |
| Uses | Melittin from honey bee venom has been used:
- In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
- To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
- As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.
|
| Definition | ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active comonent of bee venom. |
| General Description | Chemical structure: peptide |
| Biochem/physiol Actions | Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death. |
| storage | Store at -20°C |
MELITTIN Preparation Products And Raw materials
| Raw materials | FMOC-L-Arginine-->Nalpha-FMOC-L-Glutamine-->FMOC-Ala-OH-->FMOC-LYS-OH-->Fmoc-Pro-OH-->FMOC-L-Valine-->Fmoc-Leu-OH-->2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid-->Fmoc-L-Serine-->Nalpha-FMOC-L-Tryptophan-->Fmoc-Ile-OH-->Fmoc-Gly-OH |
