Introduction：Basic information about MERANZIN CAS 23971-42-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
MERANZIN Basic information
| Product Name: | MERANZIN |
| Synonyms: | MERANZIN;8-[[(S)-3,3-Dimethyloxiranyl]methyl]-7-methoxy-2H-1-benzopyran-2-one;Merancin;2H-1-Benzopyran-2-one, 8-[[(2S)-3,3-dimethyl-2-oxiranyl]methyl]-7-methoxy-;(S)-8-((3,3-Dimethyloxiran-2-yl)methyl)-7-methoxy-2H-chromen-2-one;Meranzin, 10 mM in DMSO |
| CAS: | 23971-42-8 |
| MF: | C15H16O4 |
| MW: | 260.29 |
| EINECS: | 200-158-5 |
| Product Categories: | |
| Mol File: | 23971-42-8.mol |
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MERANZIN Chemical Properties
| Melting point | 89-92 °C(Solv: ethyl ether (60-29-7)) |
| Boiling point | 414.8±45.0 °C(Predicted) |
| density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Cryst. |
| color | White to off-white |
| Optical Rotation | [α]/D -48.0 to -44.0° in chloroform (0.063 g/100 mL) |
| InChI | InChI=1S/C15H16O4/c1-15(2)12(19-15)8-10-11(17-3)6-4-9-5-7-13(16)18-14(9)10/h4-7,12H,8H2,1-3H3/t12-/m0/s1 |
| InChIKey | LSZONYLDFHGRDP-LBPRGKRZSA-N |
| SMILES | C1(=O)OC2=C(C[C@H]3C(C)(C)O3)C(OC)=CC=C2C=C1 |
| LogP | 1.920 (est) |
Safety Information
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
MERANZIN Usage And Synthesis
| Uses | Meranzin is an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS). Meranzin, isolated from leaves of Murraya exotica L., regulates the shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Meranzin has the potential for the prevention of the comorbidity of atherosclerosis and depression[1][2]. |
| target | Immunology & Inflammation related |
| References | [1] Lan Li, et al. Chaihu-Shugan-San and Absorbed Meranzin Hydrate Induce Anti-Atherosclerosis and Behavioral Improvements in High-Fat Diet ApoE -/- Mice via Anti-Inflammatory and BDNF-TrkB Pathway. Biomed Pharmacother. 2019 Jul;115:108893. DOI:10.1016/j.biopha.2019.108893
[2] Rongwei Yan, et al. Preparative Isolation and Purification of Hainanmurpanin, Meranzin, and Phebalosin From Leaves of Murraya Exotica L. Using Supercritical Fluid Extraction Combined With Consecutive High-Speed Countercurrent Chromatography. J Sep Sci. 20 DOI:10.1002/jssc.201701423 |
MERANZIN Preparation Products And Raw materials
