Introduction：Basic information about Methylaminoformyl chloride CAS 6452-47-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Methylaminoformyl chloride Basic informationDescription Uses Preparation
| Product Name: | Methylaminoformyl chloride |
| Synonyms: | METHYLCARBAMOYLCHLORIDE;METHYLAMINOFORMYL CHLORIDE;n-methylaminoformyl chloride;Methylcarbamic chloride;N-Methylchloroformamide;Methylcarbamic acid chloride;N-(Chloroformyl)methylamine;N-Methylcarbamoyl chloride |
| CAS: | 6452-47-7 |
| MF: | C2H4ClNO |
| MW: | 93.51 |
| EINECS: | 229-253-7 |
| Product Categories: | Agrochemicals |
| Mol File: | 6452-47-7.mol |
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Methylaminoformyl chloride Chemical Properties
| Melting point | 45°C |
| Boiling point | 93°C (dec.) |
| density | 1.185±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Acetonitrile, Chloroform (Slightly), DMSO |
| pka | 10.67±0.46(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability: | Air Sensitive, Hygroscopic, Moisture Sensitive, Volatile |
| InChI | InChI=1S/C2H4ClNO/c1-4-2(3)5/h1H3,(H,4,5) |
| InChIKey | GRRYSIXDUIAUGY-UHFFFAOYSA-N |
| SMILES | C(Cl)(=O)NC |
| CAS DataBase Reference | 6452-47-7(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Methylaminoformyl chloride Usage And Synthesis
| Description | Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis. |
| Uses | Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis. |
| Preparation | Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3]. |
| Uses | Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009 |
Methylaminoformyl chloride Preparation Products And Raw materials
| Raw materials | Carbon tetrachloride-->Methylamine-->PHOSGENE |
| Preparation Products | Carbofuran-->METHYLISOCYANATE 1 X 500MG NEAT-->Propoxur-->Carbaryl-->METOLCARB-->Methabenzthiazuron-->5-(Amino-1-(N-methyl Carbamoyl) |
