Introduction：Basic information about Metrizoic acid CAS 1949-45-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Metrizoic acid Basic information
| Product Name: | Metrizoic acid |
| Synonyms: | METRIZOIC ACID;3-ACETAMIDO-5-(N-METHYLACETAMIDO)-2,4,6-TRIIODOBENZOIC ACID;3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-benzoicaci;3-acetamido-2,4,6-triiodo-5-(n-methylacetamido)-benzoicaci;metrizoate;3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoic acid;3-(Acetylamino)-5-[acetyl methyl-amino)2,4,6-triiodobenzoic acid;Metrizoic |
| CAS: | 1949-45-7 |
| MF: | C12H11I3N2O4 |
| MW: | 627.94 |
| EINECS: | 217-761-1 |
| Product Categories: | Amines;Aromatics;Diagnostic;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 1949-45-7.mol |
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Metrizoic acid Chemical Properties
| Melting point | 281-282° |
| Boiling point | 678.8±55.0 °C(Predicted) |
| density | 2.3140 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO |
| form | Solid |
| pka | 0.82±0.10(Predicted) |
| color | White |
| Merck | 14,6156 |
| CAS DataBase Reference | 1949-45-7(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo- (1949-45-7) |
Safety Information
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| RTECS | DG0887300 |
| HS Code | 2924.29.7790 |
Metrizoic acid Usage And Synthesis
| Originator | Isopaque,Winthrop,France,1973 |
| Uses | Diagnosis aid (radiopaque medium). |
| Definition | ChEBI: Metrizoic acid is a monocarboxylic acid. It has a role as a radioopaque medium. |
| Manufacturing Process | 3,5-Diacetamido-2,4,6-triiodobenzoic acid (diatrizoic acid) (see Diatrizoate entry for synthesis) (10 g) is suspended in water (10 ml), 5 N potassiumhydroxide (4.3 equivalent) is added and the mixture cooled to about 15°C.Dimethyl sulfate (0.5 equivalent) dissolved in an equal volume of acetone isadded drop by drop while stirring. After the reaction mixture has been stirredfor about 1 hour hydrochloric acid (1:1) is added, with stirring to pH about0.5. The precipitate is filtered, washed and suspended moist in 4 parts ofwater, concentrated ammonia is added to pH about 7 and the ammonium saltsolution is isomerized at 90°C to 100°C for about one-half hour whereafteradditional ammonia is added to pH about 9 followed by solid ammoniumchloride (about 10% weight/volume) and the solution stirred overnight andthe excess of 3,5-diacetamide-2,4,6-triiodobenzoic acid recovered asammonium salt on the filter. The filtrate is precipitated by means ofhydrochloric acid (1:1 ) at pH about 0.5 and the N-methyl-3,5-diacetamido-2,4,6-triiodobenzoic acid collected on a filter, washed and dried. |
| Therapeutic Function | Diagnostic aid (radiopaque medium) |
Metrizoic acid Preparation Products And Raw materials
| Raw materials | Dimethyl sulfate |
