N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO CAS 102-65-8

Introduction：Basic information about N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO CAS 102-65-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO Basic information

• Product Name: N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO
• Synonyms: N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO SODIUM MONOHYDRATE;SULFACHLOROPYRAZINE SODIUM;SULFACHLOROPYRAZINE SODIUM H2O;SULFACHLORPYRAZINE SODIUM;sulfaclozine;SULFACLOZINE SODIUM;SPZ;SULFACHLOROPYRAZINE SODIUM(SPZ):N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO SODIUM MONOHYDRATE
• CAS: 102-65-8
• MF: C10H9ClN4O2S
• MW: 284.72
• EINECS: 203-044-0
• Product Categories: pharmaceutical;Pharmaceutical intermediate;1;102-65-8
• Mol File: 102-65-8.mol

N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO Chemical Properties

• Melting point: 234.8-235.4 °C
• Boiling point: 495.7±55.0 °C(Predicted)
• density: 1.588±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C(protect from light)
• solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• pka: 4.83±0.10(Predicted)
• form: Solid
• color: White to Off-White

N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO Usage And Synthesis

Uses

Sulfachloropyrazine sodium monohydrate is an antiprotozoal useful in coccidiosis research.

in vivo

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections^[1].

• Animal Model: 14 male broiler chickens (30-day-old)^[1]
• Dosage: 60 mg/kg
• Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis)
• Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.

IC 50

Coccidia