Introduction：Basic information about N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride CAS 2107273-00-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride Basic information
| Product Name: | N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride |
| Synonyms: | N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride;N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 |
| CAS: | 2107273-00-5 |
| MF: | C43H58ClN5O7 |
| MW: | 792.42 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 2107273-00-5.mol |
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N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride Chemical Properties
| solubility | Soluble in DMSO, DMF, DCM, low solubility in water |
Safety Information
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride Usage And Synthesis
| Description | N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 is a Cy7 labeled near infrared fluorescent PEG linker containing an azide group, which enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. This reagent can be utilized to produce Cy7-labeled biomolecules for potential in vivo research and drug design related experiments. |
| Uses | N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. |
| IC 50 | PEGs |
| References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride Preparation Products And Raw materials
