N-(Trimethylsilyl)imidazole CAS 18156-74-6
Introduction：Basic information about N-(Trimethylsilyl)imidazole CAS 18156-74-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-(Trimethylsilyl)imidazole Basic information
| Product Name: | N-(Trimethylsilyl)imidazole |
| Synonyms: | 1-(TRIMETHYLSILYL)IMIDAZOLE, 97%1-(TRIMETHYLSILYL)IMIDAZOLE, 97%1-(TRIMETHYLSILYL)IMIDAZOLE, 97%;Trimethylimidazosilane;Trimethylsilylimidzole;1-(trimethylsilyl)-1h-imidazol;1-(trimethylsilyl)-imidazol;1-Imidazolyltrimethylsilane;CT3600;Imidazole, 1-(trimethylsilyl)- |
| CAS: | 18156-74-6 |
| MF: | C6H12N2Si |
| MW: | 140.26 |
| EINECS: | 242-040-3 |
| Product Categories: | Silylation Reagents;Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Silylation (GC Derivatizing Reagents);Silylimidazoles;Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents);Silicon Compounds (for Synthesis);Synthetic Organic Chemistry;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C3 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles;Special Silanes;bc0001 |
| Mol File: | 18156-74-6.mol |
N-(Trimethylsilyl)imidazole Chemical Properties
| Melting point | -42 °C |
| Boiling point | 93-94 °C14 mm Hg(lit.) |
| density | 0.957 g/mL at 20 °C |
| refractive index | n |
| Fp | 42 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform |
| form | Liquid |
| pka | 7.96±0.10(Predicted) |
| color | Clear colorless to yellow |
| Specific Gravity | 0.956 |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 606148 |
| Stability: | Air and Moisture Sensitive |
| InChI | 1S/C6H12N2Si/c1-9(2,3)8-5-4-7-6-8/h4-6H,1-3H3 |
| InChIKey | YKFRUJSEPGHZFJ-UHFFFAOYSA-N |
| SMILES | C[Si](C)(C)n1ccnc1 |
| CAS DataBase Reference | 18156-74-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 1h-Imidazole, 1-(trimethylsilyl)-(18156-74-6) |
| EPA Substance Registry System | 1H-Imidazole, 1-(trimethylsilyl)- (18156-74-6) |
Safety Information
| Hazard Codes | F,Xi,C |
| Risk Statements | 11-36/37/38-14-40-34-37-35-20/21/22 |
| Safety Statements | 16-26-33-37/39-45-36/37/39 |
| RIDADR | UN 1993 3/PG 2 |
| WGK Germany | 3 |
| RTECS | NI8700000 |
| F | 10-21 |
| Autoignition Temperature | 540 °C DIN 51794 |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29332990 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 Skin Irrit. 2 |
| Chemical Properties | Colorless transparent liquid |
| Physical properties | bp 93–94 °C/14 mmHg; fp 5 °C; d 0.956 g cm?3. |
| Uses | N-(trimethylsilyl) imidazole (TMSim) is quite reactive with hydroxyl groups in a variety of analytes including a variety of lipids.As with other derivatization reactions,microwave heating can greatly improve process efficiency. |
| Uses | N-(Trimethylsilyl)imidazole is a silylating agent for alcohols and 1,3-dicarbonyl compounds; reaction with esters to give imidazolides; preparation ofO-trimethylsilyl monothioacetals; aromatization of the A-ring of steroids. It participates in the reactions of Hydroxyl Silylation Reactions, Silyl Aminal Formation Reactions, Nitrogen Silylation Reactions, Acyl Imidazole Formation, Michael Addition Reactions, Substitution Reactions, Phosphoroimidazolidate Formation, and other uses. |
| Uses | A general silylating agent, particularly for alcohols. An intermediate for the synthesis of imidazole derivatives. |
| Uses | Silylating reagent for the protection of hydroxyl groups in the presence of amine functionalities.1 |
| Definition | ChEBI: A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a trimethylsilyl group. N-trimethylsilylimidazole is a derivatisation agent used in gas chromatography/mass spectrometry applications. |
| General Description | 1-(Trimethylsilyl)imidazole (TMSIM) has high silyl donor ability. It does not react with amino groups and also does not help in formation of enol-ether on unprotected ketone groups. It is useful as a silylating agent for ecdysones, norepinephrine, dopamine, steroids, sugars, sugar phosphates and ketose isomers. |
| reaction suitability | reagent type: derivatization reagent reaction type: Silylations |
N-(Trimethylsilyl)imidazole Preparation Products And Raw materials
| Preparation Products | Medetomidine-->4-TRIMETHYLSILOXY-3-PENTEN-2-ONE-->Chlorotrimethylsilane-->1,1'-Sulfonyldiimidazole-->N,N'-BIS(IMIDAZOLE)DIMETHYLSILANE,TECH-95-->2-O,3-O,4-O,5-O-Tetrakis(trimethylsilyl)-D-ribose-->1,1'-Thiocarbonyldiimidazole |
