Introduction：Basic information about N,N,N',N'-Tetramethylazodicarboxamide CAS 10465-78-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Table of Contents
- 1. N,N,N',N'-Tetramethylazodicarboxamide Basic informationDescription References
- 2. N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties
- 3. Safety Information
- 4. N,N,N',N'-Tetramethylazodicarboxamide Usage And Synthesis
- 5. N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials
N,N,N',N'-Tetramethylazodicarboxamide Basic informationDescription References
| Product Name: | N,N,N',N'-Tetramethylazodicarboxamide |
| Synonyms: | AZODICARBOXYLIC ACID BIS[DIMETHYLAMIDE];DIAMIDE;DIAZINE-DICARBOXYLIC ACID BIS[N,N-DIMETHYLAMIDE];1,1'-AZOBIS(N,N'-DIMETHYLFORMAMIDE);1,1'-AZOBIS(N,N-DIMETHYLFORMAMIDE);N,N,N',N'-TETRAMETHYLAZODICARBAMIDE;1,1’-azobis(n,n-dimethyl-formamid;n,n,n’,n’-tetramethylazoformamide |
| CAS: | 10465-78-8 |
| MF: | C6H12N4O2 |
| MW: | 172.19 |
| EINECS: | 233-951-7 |
| Product Categories: | proteinmod;Azodicarboxylates & Amides;Mitsunobu Reaction;Synthetic Organic Chemistry |
| Mol File: | 10465-78-8.mol |
|
N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties
| Melting point | 112 °C |
| Boiling point | 220.4±23.0 °C(Predicted) |
| density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | soluble in Methanol |
| form | crystalline |
| pka | -0?+-.0.70(Predicted) |
| color | yellow |
| Water Solubility | water: 19.60-21.00mg/mL, clear to slightly hazy, orange |
| BRN | 1910409 |
| InChI | InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+ |
| InChIKey | VLSDXINSOMDCBK-BQYQJAHWSA-N |
| SMILES | C(=O)(/N=N/C(=O)N(C)C)N(C)C |
| CAS DataBase Reference | 10465-78-8(CAS DataBase Reference) |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | LQ1041000 |
| F | 4.10 |
| HS Code | 29270000 |
| Storage Class | 11 - Combustible Solids |
N,N,N',N'-Tetramethylazodicarboxamide Usage And Synthesis
| Description | N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications. |
| References | N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133 |
| Chemical Properties | Yellow crystals |
| Uses | Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation. |
| Definition | ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007 |
N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials
| Raw materials | Dichloromethane-->Triethylamine-->HYDRAZINE-->Dimethylcarbamoyl chloride-->Silver oxide |
| Preparation Products | 1-amino-9,10-dihydro-9,10-dioxoanthracene-2-carbaldehyde 2-[(1-amino-9,10-dihydro-9,10-dioxo-2-anthryl)methylene]hydrazone-->1H-Indazole-3-diazonium, 6-chloro- |
