Introduction：Basic information about Naphazoline nitrate CAS 5144-52-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Naphazoline nitrate Basic information
| Product Name: | Naphazoline nitrate |
| Synonyms: | NAPHAZOLINE NITRATE;NAPHAZOLINE NITRATE SALT;NAPHAZOLINI NITRAS;LABOTEST-BB LT00134653;2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM NITRATE;2-(1-NAPHTHYLMETHYL)IMIDAZOLINE NITRATE;2-[1-NAPHTHYLMETHYL]IMIDAZOLINE NITRATE SALT;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE NITRATE |
| CAS: | 5144-52-5 |
| MF: | C14H15N3O3 |
| MW: | 273.29 |
| EINECS: | 225-915-4 |
| Product Categories: | API |
| Mol File: | 5144-52-5.mol |
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Naphazoline nitrate Chemical Properties
| Melting point | 167-170 °C |
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to off-white |
| Sensitive | Hygroscopic |
| BRN | 3779329 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4) |
| InChIKey | ZAHXYMFVNNUHCP-UHFFFAOYSA-N |
| SMILES | C12C(C=CC=C1)=CC=CC=2CC1=NCCN1.[N+]([O-])(=O)O |
| CAS DataBase Reference | 5144-52-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-36/37-60-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | NJ4376000 |
| F | 3-10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29332900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Naphazoline nitrate Usage And Synthesis
| Chemical Properties | White or almost white, crystalline powder. |
| Uses | antihistamine |
| Indications | Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977). |
| Definition | ChEBI: Naphazoline nitrate is a member of naphthalenes. |
| in vivo | Naphazoline nitrate (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1]. | Animal Model: | Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1] | | Dosage: | 0.2 mg/mL, 10 μl per eye | | Administration: | Intraperitoneal injection (IP), once | | Result: | Significantly suppressed conjunctival dye leakage in mice with histamine or antigen?induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice. |
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| IC 50 | IL-1β; IL-6; IL-4 |
Naphazoline nitrate Preparation Products And Raw materials
| Raw materials | 1-Naphthaleneacetic acid |
| Preparation Products | Neomycin |
