Introduction：Basic information about N-desalkylflurazepam CAS 2886-65-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-desalkylflurazepam Basic information
| Product Name: | N-desalkylflurazepam |
| Synonyms: | NORFLUDIAZEPAM;Dealkylflurazepam;Descarbethoxyloflazepate;Flurazepam M (des-alkyl);Flurazepam M (N-1-des-alkyl);Flurazepam, des-alkyl;N-1-desalkyl-flurazepam;N-Desalkyl-2-oxoquazepam |
| CAS: | 2886-65-9 |
| MF: | C15H10ClFN2O |
| MW: | 288.7 |
| EINECS: | 220-748-3 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles;(intermediate of fludiazepam,flurazepam);pharmacetical;medical intermediate |
| Mol File: | 2886-65-9.mol |
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N-desalkylflurazepam Chemical Properties
| Melting point | 204-206°C |
| Boiling point | 454.0±45.0 °C(Predicted) |
| density | 1.39±0.1 g/cm3(Predicted) |
| Fp | 9℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | A neat solid |
| pka | 11.55±0.70(Predicted) |
| color | White to off-white |
| Major Application | pharmaceutical |
| InChI | InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20) |
| InChIKey | UVCOILFBWYKHHB-UHFFFAOYSA-N |
| SMILES | N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O |
| CAS DataBase Reference | 2886-65-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Norfludiazepam(2886-65-9) |
Safety Information
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 22-24/25-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | DF2370100 |
| HS Code | 2933997500 |
| Storage Class | 13 - Non Combustible Solids |
| Hazard Classifications | STOT SE 3 |
N-desalkylflurazepam Usage And Synthesis
| Description | Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications. |
| Chemical Properties | Light Yellow Solid |
| Uses | The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase |
| Definition | ChEBI: Desalkylflurazepam is a benzodiazepine. |
| General Description | N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward. |
| Mode of action | N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward. |
| References | [1] DAMIEN E EARL E I T. Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 2011, 337 1: 301-311. DOI: 10.1124/jpet.110.178244
[2] STEPHANIE J MARIN. Quantitation of benzodiazepines in urine, serum, plasma, and meconium by LC-MS-MS.[J]. Journal of analytical toxicology, 2008, 32 7: 491-498. DOI: 10.1093/jat/32.7.491 |
N-desalkylflurazepam Preparation Products And Raw materials
| Raw materials | 7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine-->2-bromo-4'-chloro-2'-(o-fluorobenzoyl)acetanilide-->2-chloro-N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide-->BOC-Glycine |
| Preparation Products | Flualprazolam-->2-Amino-5-chloro-2'-fluorobenzophenone-->4-Imidazolidinone, 1,1'-methylenebis[3-[4-chloro-2-(o-fluorobenzoyl)phenyl]- (7CI,8CI)-->Midazolam-->[7-CHLORO-5-(2-FLUORO-PHENYL)-3H-BENZO[E][1,4]DIAZEPIN-2-YL]-METHYL-AMINE |
