Nedaplatin CAS 95734-82-0
Introduction：Basic information about Nedaplatin CAS 95734-82-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Nedaplatin Basic information
| Product Name: | Nedaplatin |
| Synonyms: | (glycolato-o,o')diammineplatinum(ii);cis-diammine(glycolato)platinum(ii);NEDAPLATIN;254-s;Aqupla;cis-diamine-glycolate-O,O'-platinum(II);o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu;Nedaplait |
| CAS: | 95734-82-0 |
| MF: | C2H6N2O3Pt |
| MW: | 301.17 |
| EINECS: | |
| Product Categories: | Inhibitors;Anticancer;Anticancer Platinum Agent |
| Mol File: | 95734-82-0.mol |
Nedaplatin Chemical Properties
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity) |
| form | Powder |
| color | Light yellow to yellow |
| InChI | InChI=1S/C2H3O3.2H2N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H2;/q3*-1;+4/p-1 |
| InChIKey | GRHLMSBCOPRFNA-UHFFFAOYSA-M |
| SMILES | N[Pt+2]1([O-]CC(=O)[O-]1)N |
Safety Information
| WGK Germany | WGK 3 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Oral Carc. 1B Eye Irrit. 2 Resp. Sens. 1B Skin Irrit. 2 Skin Sens. 1B STOT SE 3 |
| Description | Nedaplatin, a novel second generation platinum complex, was marketedin Japan for the treatment of a variety of cancers including: head and neck, small-celland non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder,and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have beenreported to be hydrolyzed to the mono- or diaquated species of diamine platinum whichreact with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks andDNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly moreactive than cisplatin against several solid tumors while sharing less nephro- andgastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed bynedaplatin allows its use in patients with deteriorated renal function. |
| Originator | Shionogi (Japan) |
| Uses | anticancer |
| Uses | Nedaplatin is a platinum complex that has potent antineoplatic activity. |
| Brand name | Aqupla |
| Pharmaceutical Applications | Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin.The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleavinggroups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatinhas been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular,ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effectis myelosuppression. |
Nedaplatin Preparation Products And Raw materials
