Introduction：Basic information about Nebivolol CAS 99200-09-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Nebivolol Basic information
| Product Name: | Nebivolol |
| Synonyms: | NEBIVOLOL-D4;1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol;Nibivolol;Nebivolol Impurity 6(rac-Nebivolol (Mixture of Diastereomers));2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol);rac-Nebivolol (Mixture of Diastereomers);1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]ethanol;R-65824 |
| CAS: | 99200-09-6 |
| MF: | C22H25F2NO4 |
| MW: | 405.43 |
| EINECS: | |
| Product Categories: | Antihypertensive |
| Mol File: | 99200-09-6.mol |
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Nebivolol Chemical Properties
| Boiling point | 600.5±55.0 °C(Predicted) |
| density | 1.309±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 14.29±0.20(Predicted) |
| color | White to Off-White |
| InChI | InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/s3/i11D2,12D2 |
| InChIKey | KOHIRBRYDXPAMZ-AWIIVWKDNA-N |
| SMILES | C([2H])([2H])([C@H](O)[C@@]1([H])CCC2C=C(C=CC=2O1)F)NC([2H])([2H])[C@H](O)[C@]1([H])CCC2C=C(C=CC=2O1)F |&1:3,5,21,23,r| |
| CAS DataBase Reference | 99200-09-6(CAS DataBase Reference) |
Safety Information
Nebivolol Usage And Synthesis
| Description | Nebilet was launched in Germany and the Netherlands as anantihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4-oxobenzopyran-2-carboxylic acid. It is a selective β1-adrenergic receptor antagonistand is 50 times less potent at β2-receptors. Vasodialating properties occur via thenitric oxide pathway. While the L-isomer is more potent than the D-isomer, theracemic mixture is necessary for optimal activity. Upon administration, an immediatefall in blood pressure occurs, it improves both left ventricular systolic and diastolicfunction, and lowers peripheral blood resistance. Nebilet does not influence insulinsensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10mg of Nebilet are equipotent but Nebilet has a longer duration of action due to anaccumulation of the drug and increasing plasma levels of active metabolites. |
| Originator | Johnson & Johnson (US) |
| Uses | Nebivolol is a cardioselective beta-1 receptor blocking agent. |
| Uses | Labeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry. |
| Definition | ChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group. |
| Brand name | Nebilet |
Nebivolol Preparation Products And Raw materials
| Preparation Products | NEBIVOLOL |
