Introduction：Basic information about Nexopamil (racemate) CAS 116759-35-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Nexopamil (racemate) Basic information
| Product Name: | Nexopamil (racemate) |
| Synonyms: | Nexopamil (racemate);5-[N-methyl-N-(n-hexyl)]-amino-2-(3,4,5-trimethoxyphenyl)-2-isopropylvaleronitrile;Benzeneacetonitrile, α-[3-(hexylmethylamino)propyl]-3,4,5-trimethoxy-α-(1-methylethyl)- |
| CAS: | 116759-35-4 |
| MF: | C24H40N2O3 |
| MW: | 404.6 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 116759-35-4.mol |
|
Nexopamil (racemate) Chemical Properties
| Boiling point | 514.7±50.0 °C(Predicted) |
| density | 0.985±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9?+-.0.50(Predicted) |
Safety Information
Nexopamil (racemate) Usage And Synthesis
| Uses | Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro. |
| in vivo | Nexopamil (0.05 mg/kg) completely abolishes cyclic flow reductions (CFRs) during the first 30 min after application without significantly altering hemodynamics[1]. |
| IC 50 | 5-HT2 Receptor |
| References | [1] Kirchengast M, et al. Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94. DOI:10.1097/00005344-199311000-00003 |
Nexopamil (racemate) Preparation Products And Raw materials
