Introduction：Basic information about NICLOFOLAN CAS 10331-57-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
NICLOFOLAN Basic information
| Product Name: | NICLOFOLAN |
| Synonyms: | NICLOFOLAN;Niclofoian;1'-biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-(;3,3'-dichloro-5,5'-dinitro-o,o'-biphenol;4,4'-dichloro-6,6'-dinitro-o,o'-biphenol;5,5'-dichloro-2,2'-dihydroxy-3,3'-dinitrobiphenyl;5,5'-dichloro-3,3'-dinitro(1,1'-biphenyl)-2,2'-diol;menichlopholan |
| CAS: | 10331-57-4 |
| MF: | C12H6Cl2N2O6 |
| MW: | 345.09 |
| EINECS: | 233-720-0 |
| Product Categories: | API |
| Mol File: | 10331-57-4.mol |
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NICLOFOLAN Chemical Properties
| Boiling point | 251.5°C (rough estimate) |
| density | 1.8594 (rough estimate) |
| refractive index | 1.7350 (estimate) |
| form | Solid |
| pka | 4.34±0.40(Predicted) |
| color | Light yellow to yellow |
| EPA Substance Registry System | Niclofolan (10331-57-4) |
Safety Information
| Toxicity | bird - wild,LD50,oral,13mg/kg (13mg/kg),Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. |
NICLOFOLAN Usage And Synthesis
| Chemical Properties | Orange-yellow crystalline powder. Melting point 178-182 ℃. Soluble in acetone, glacial acetic acid and sodium hydroxide solution, slightly soluble in water and ethanol. |
| Uses | Niclofolan can be used as deworming drug and anti-creep drug. It is used for prevention and treatment of hepatic chioniasis of cattle and sheep. |
| Definition | ChEBI: Niclofolan is a polychlorobiphenyl. |
| Synthesis | Niclofolan is obtained by nitration of 5,5 '-dichloro-2, 2' dihydroxybiphenyl. The nitration was carried out in acetic acid at a temperature not exceeding 20℃. Then activated carbon was added for reflux decolorization for 1h. The filter was pumped with a nitrate filter rod. The filtrate was cooled below 15℃ and crystallized. Dinitrochlorophenol was obtained by filtration, washing with acetic acid and drying. The yield is 60%. |
| in vivo | Niclofolan (2 mg/kg, intramuscular injection) is effective against fasciola hepatica infected sheep[2].
Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats[4].
| Animal Model: | fasciola hepatica infected sheep[2] | | Dosage: | 2 mg/kg | | Administration: | Intramuscular injection | | Result: | Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection.| Animal Model: | Rats infected with P.iloktsuenesis[4] | | Dosage: | 1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times. | | Administration: | Oral gavage | | Result: | Reduced the worms in rats. |
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NICLOFOLAN Preparation Products And Raw materials| Raw materials | Thionyl chloride-->1,3-Bisbenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid-->Dibenzofuran |
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