N-Methyl-N-(trimethylsilyl)trifluoroacetamide CAS 24589-78-4
Introduction：Basic information about N-Methyl-N-(trimethylsilyl)trifluoroacetamide CAS 24589-78-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Basic information
| Product Name: | N-Methyl-N-(trimethylsilyl)trifluoroacetamide |
| Synonyms: | N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE W. 1% TMCS;N-METHYL-N-(TRIMETHYLSILYL)TRIFLUORO-ACE TAMIDE, DERIVATIZATION GRADE;N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACET-A MIDE, FOR GC;N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAM, 10x1ML PACKSIZE;N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE 98%;N-Methyl-N-(Trimethylsily)Trifluoroacetamide;N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 98;MSTFA~N-Trimethylsilyl-N-methyltrifluoroacetamide |
| CAS: | 24589-78-4 |
| MF: | C6H12F3NOSi |
| MW: | 199.25 |
| EINECS: | 246-331-6 |
| Product Categories: | Silylation Reagents;Amines;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Silylation (GC Derivatizing Reagents);Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents);Reagents for SilylationProtection and Derivatization;Silicon-BasedAnalytical/Chromatography;Protecting and Derivatizing Reagents;Silylation Reagents;Derivatization Reagents;Derivatization Reagents GC;Reagents for SilylationAnalytical/Chromatography;Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Silylacetamides;Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol File: | 24589-78-4.mol |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties
| Melting point | 98-100°C |
| Boiling point | 130132°C |
| density | 1.075 g/mL at 25 °C(lit.) |
| vapor density | >1 (vs air) |
| vapor pressure | 8.8 mm Hg ( 27 °C) |
| refractive index | n |
| Fp | 77 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | -1.34±0.70(Predicted) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.076 |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1941550 |
| Major Application | forensics and toxicology |
| InChI | 1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3 |
| InChIKey | MSPCIZMDDUQPGJ-UHFFFAOYSA-N |
| SMILES | CN(C(=O)C(F)(F)F)[Si](C)(C)C |
| CAS DataBase Reference | 24589-78-4(CAS DataBase Reference) |
| EPA Substance Registry System | Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4) |
Safety Information
| Hazard Codes | Xi,F,T,N |
| Risk Statements | 10-36/37/38-61-50/53-51/53 |
| Safety Statements | 26-36-37/39-16-45-53-61 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | AC9800000 |
| F | 10-21 |
| Hazard Note | Flammable |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29319090 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | Clear colorless to light yellow liquid |
| Uses | A new metabolite of Famprofazone in humans. |
| Uses | N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone. |
| Definition | ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivatsation agent used in gas chromatography/mass spectrometry applications. |
| General Description | N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane. |
| reaction suitability | reagent type: derivatization reagent reaction type: Silylations |
| Purification Methods | Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.] |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials
| Raw materials | N,O-Bis(trimethylsilyl)acetamide-->N-Methyl-2,2,2-trifluoroacetamide |
