O-PHOSPHORYLETHANOLAMINE CAS 1071-23-4

Introduction：Basic information about O-PHOSPHORYLETHANOLAMINE CAS 1071-23-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

O-PHOSPHORYLETHANOLAMINE Basic information

• Product Name: O-PHOSPHORYLETHANOLAMINE
• Synonyms: ETHANOLAMINE PHOSPHATE;2-HYDROXYETHYLAMMONIUM DIHYDROGEN PHOSPHATE;2-HYDROXYETHYLAMINE ACID PHOSPHATE;2-AMINOETHANOL DIHYDROGEN PHOSPHATE;2-AMINOETHYL DIHYDROGEN PHOSPHATE;O-PHOSPHOETHANOLAMINE;O-PHOSPHORYLETHANOLAMINE;O-PHOSPHOCOLAMINE
• CAS: 1071-23-4
• MF: C2H8NO4P
• MW: 141.06
• EINECS: 213-988-5
• Product Categories: Pharmaceutical Intermediates
• Mol File: 1071-23-4.mol

O-PHOSPHORYLETHANOLAMINE Chemical Properties

• Melting point: 241-243 °C(lit.)
• Boiling point: 335.8±44.0 °C(Predicted)
• density: 1.554±0.06 g/cm3(Predicted)
• storage temp.: Store below +30°C.
• Water Solubility: Soluble in water
• solubility: PBS (pH 7.2): 10 mg/ml
• pka: pK1:5.838(+1);pK2:10.638(0) (25°C)
• form: powder to crystal
• color: White to Light yellow
• BRN: 1758916
• InChI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)
• InChIKey: SUHOOTKUPISOBE-UHFFFAOYSA-N
• SMILES: C(OP(O)(O)=O)CN
• CAS DataBase Reference: 1071-23-4(CAS DataBase Reference)
• EPA Substance Registry System: Ethanol, 2-amino-, dihydrogen phosphate (ester) (1071-23-4)

Safety Information

• Hazard Codes: T,C
• Risk Statements: 25-34
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: KJ5830000
• TSCA: TSCA listed
• HazardClass: 8
• PackingGroup: III
• HS Code: 29221990
• Storage Class: 11 - Combustible Solids
• Toxicity: LD50 orally in Rabbit: 5820 mg/kg

O-PHOSPHORYLETHANOLAMINE Usage And Synthesis

Chemical Properties

O-PHOSPHORYLETHANOLAMINE is white powder

Uses

O-PHOSPHORYLETHANOLAMINEe is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane.

Uses

O-Phosphorylethanolamine has been used:

• in LHC-8 medium as a supplement in culturing the transformed human liver epithelial (THLE)-2 and THLE-3 cells
• in C-reactive protein (CRP) binding sucrose flotation experiment
• to incubate phosphomonoesters with anion-exchange chromatography (AEC) fractions for the detection of phosphatase activity
• to add in the washed beads for the preparation of phosphorylethanolamine (Pet) -conjugated sepharose column for chromatographic purification of mutant CRP

Definition

ChEBI: The ethanolamine mono-ester of phosphoric acid, and a metabolite of phospholipid metabolism. This phosphomonoester shows strong structural similarity to the inhibitory neurotransmitter GABA, and is decreased in post-mortem Alzheimer's disease brain.

Biochem/physiol Actions

Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer′s and Huntington′s disease.

Purification Methods

Purification by recrystallisation from aqueous EtOH gives a hydrate (m 140-141o). Its solubility in H2O is 17% and 0.003% in MeOH or EtOH at 22o. [F.lisch & .sterberg J Biol Chem 234 2298 1959, Baer & Staucer Can J Chem 34 434 1956, Christensen J Biol Chem 135 399 1940.] It is a potent inhibitor of ornithine decarboxylase [Gilad & Gilad Biochem Biophys Res Commun 122 277 1984]. [Beilstein 4 IV 1415.]