Introduction：Basic information about O-TOLUENESULFONYL CHLORIDE CAS 133-59-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
O-TOLUENESULFONYL CHLORIDE Basic information
| Product Name: | O-TOLUENESULFONYL CHLORIDE |
| Synonyms: | ortho-toluenesulfonylchloride;o-Toluenesulfochloride;o-tolylsulfonylchloride;o-Tosyl chloride;o-tosylchloride;toluene-2-sulphonylchloride;ortho-toluenesulfonchloride;Paroxetine Impurity 30 |
| CAS: | 133-59-5 |
| MF: | C7H7ClO2S |
| MW: | 190.65 |
| EINECS: | 205-113-0 |
| Product Categories: | Organic Building Blocks;Sulfonyl Halides;Intermediates of Dyes and Pigments;Sulfur Compounds |
| Mol File: | 133-59-5.mol |
|
O-TOLUENESULFONYL CHLORIDE Chemical Properties
| Melting point | 10°C |
| Boiling point | 254 °C(lit.) |
| density | 1.320 g/mL at 25 °C(lit.) |
| refractive index | n20/D >1.5580(lit.) |
| Fp | >230 °F |
| storage temp. | Store under inert gas |
| solubility | Acetonitrile (Slightly), Chloroform(Slightly) |
| form | clear liquid |
| color | Colorless to Light yellow |
| Water Solubility | Soluble in hot alcohol, ether and benzene. Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 973180 |
| InChI | InChI=1S/C7H7ClO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3 |
| InChIKey | HDECRAPHCDXMIJ-UHFFFAOYSA-N |
| SMILES | C1(S(Cl)(=O)=O)=CC=CC=C1C |
| CAS DataBase Reference | 133-59-5(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenesulfonyl chloride, 2-methyl- (133-59-5) |
Safety Information
| Hazard Codes | C,Xi |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| Hazard Note | Corrosive |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 2904100090 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B |
| Hazardous Substances Data | 133-59-5(Hazardous Substances Data) |
O-TOLUENESULFONYL CHLORIDE Usage And Synthesis
| Chemical Properties | Oily liquid. Melting point 10.2°C, boiling point 154°C (4.8kPa), 126°C (1.33kPa), relative density 1.3383 (20/4°C), refractive index 1.5565. soluble in hot alcohols, ethers, benzene, insoluble in water. |
| Uses | o-Toluenesulfonyl chloride is used in organic synthesis and saccharin production. It is also used as pharmaceutical intermediate. |
| Uses | o-Toluenesulfonyl chloride may be used in the synthesis of:
- oxazoline
- mesityl o-tolyl sulfone
- allyl o-toluenesulfonate
- 2-methyl-4′-t-butyldiphenyl sulfone
|
| General Description | o-Toluenesulfonyl chloride can be synthesized by reacting o-thiocresol in glacial acetic acid with chlorine. It participates in the preparation of 5-chloro-3-phenyl-2,1-benzisoxazole. |
O-TOLUENESULFONYL CHLORIDE Preparation Products And Raw materials
| Raw materials | 2-methylbenzenesulfinic acid-->o-Toluenesulfonic acid, sodium salt-->Carbamothioic acid, diethyl-, S-(2-methylphenyl) ester-->2-Methylbenzenethiol-->2-Tolylboronic acid-->Toluene |
| Preparation Products | Tosyl chloride-->Saccharin sodium-->2-Methylbenzene-1-sulfonamide-->2-Chlorobenzoyl chloride-->ETHYL-O-TOLYL KETONE-->2-TOLUENESULFONIC ACID-->2-METHYLPHENYLBORONIC ACID, PINACOL ESTER-->o-Toluenesulfonic acid, methyl ester-->N-Methyl-o-toluenesulfonamide |
