Pamidronic acid CAS 40391-99-9
Introduction：Basic information about Pamidronic acid CAS 40391-99-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Pamidronic acid Basic information
| Product Name: | Pamidronic acid |
| Synonyms: | PAMIDRONIC ACID;PAMIDRONIC ACID SODIUM SALT;Rescriptor;amidronate;DLV;(3-amino-1-hydroxypropylidene)bisphosphonic acid;(3-Amino-1-hydroxypropylidene)diphosphonic acid;3-AMINO-1-HYDROXY-1,1-PROPANEDIPHOSPHONIC ACID |
| CAS: | 40391-99-9 |
| MF: | C3H11NO7P2 |
| MW: | 235.07 |
| EINECS: | 254-905-2 |
| Product Categories: | (intermediate of pamidronate disodium);Delavirdine;API |
| Mol File: | 40391-99-9.mol |
Pamidronic acid Chemical Properties
| Melting point | 226-228°C |
| Boiling point | 658.7±65.0 °C(Predicted) |
| density | 1.998±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Methanol (Very Slightly, Heated, Sonicated), Water (Slightly, Heated, Sonicated) |
| pka | 1.44±0.10(Predicted) |
| form | Solid |
| color | Light Brown to Beige |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11) |
| InChIKey | WRUUGTRCQOWXEG-UHFFFAOYSA-N |
| SMILES | C(P(=O)(O)O)(P(=O)(O)O)(O)CCN |
Safety Information
| HS Code | 9999999999 |
| Chemical Properties | White Solid |
| Originator | Aredia,Novartis,India |
| Uses | A biphosphonate bone resorption inhibitor. |
| Uses | anticancer |
| Definition | ChEBI: Pamidronate is a phosphonoacetic acid. |
| Manufacturing Process | For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water. |
| Brand name | Rescriptor (Agouron). |
| Therapeutic Function | Bone resorption suppressant |
| References | [1] Patent: WO2016/199111, 2016, A1. Location in patent: Paragraph 00134-00135 [2] Patent: US10081572, 2018, B2. Location in patent: Page/Page column 9 [3] Russian Journal of Bioorganic Chemistry, 2012, vol. 38, # 2, p. 224 - 229 [4] Letters in Drug Design and Discovery, 2016, vol. 13, # 6, p. 475 - 478 [5] Letters in Drug Design and Discovery, 2016, vol. 13, # 6, p. 475 - 478 |
Pamidronic acid Preparation Products And Raw materials
| Raw materials | Phosphorus trichloride-->Activated carbon,decolor-->β-Alanine-->Disodium pamidronate-->Sodium hydroxide-->Mannitol |
