Panaxadiol CAS 19666-76-3

Introduction：Basic information about Panaxadiol CAS 19666-76-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Panaxadiol Basic information

• Product Name: Panaxadiol
• Synonyms: PANAXADIOL;DAMMARANE-3BETA,12BETA-DIOL;PANAXADIOL 98.0% BY HPLC;(20R)-20,25-Epoxy-5α-dammarane-3β,12β-diol;(20R)-Panaxadiol;PALMITIC ACID METHYLESTER 99%(RG) (SEE METHYL PALMITATE);Panaxadiol ,98%;Panaxaidol
• CAS: 19666-76-3
• MF: C30H52O3
• MW: 460.73
• Product Categories: Inhibitors;standardized herbal extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;Steroids;Ginseng series
• Mol File: 19666-76-3.mol

Panaxadiol Chemical Properties

• Melting point: 250℃
• Boiling point: 531.3±45.0 °C(Predicted)
• density: 1.025±0.06 g/cm3(Predicted)
• storage temp.: Refrigerator
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• form: Solid
• pka: 14.82±0.70(Predicted)
• color: White to Off-White
• InChIKey: PVLHOJXLNBFHDX-VOXQHZRYNA-N
• SMILES: [C@@]12(C)CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]1([H])C[C@@H](O)[C@]1([H])[C@H](CC[C@@]21C)[C@@]1(C)CCCC(C)(C)O1 |&1:0,4,9,13,15,18,20,22,25,27,r|
• CAS DataBase Reference: 19666-76-3

Safety Information

• Safety Statements: 24/25
• WGK Germany: WGK 3
• HS Code: 29329990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral

Panaxadiol Usage And Synthesis

Chemical Properties

White solid

Uses

Panaxadiol is the purified sapogenin of ginseng saponins, which exhibits anti-tumor activity. Research has shown Panaxadiol exhibited enhancing activity towards human colorectal cancer cells.

Definition

ChEBI: Panaxadiol is a triterpenoid saponin.

in vivo

Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model^[1].

• Animal Model: BALB/c athymic nude mice injected with HCT116 cells^[1]
• Dosage: 10 or 30 mg/kg
• Administration: Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days
• Result: Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner.

Panaxadiol Preparation Products And Raw materials

• Raw materials: Ginseng extract