Pancreatin CAS 8049-47-6
Introduction：Basic information about Pancreatin CAS 8049-47-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Pancreatin Basic information
| Product Name: | Pancreatin |
| Synonyms: | beefviokase;diastasevera;ilozyme;intrazyme;PANCREATIN;PANCREATIN, 3X;PANCREATIN 4X NF;PANCREATIN 4X USP GRANULAR |
| CAS: | 8049-47-6 |
| MF: | N/A |
| MW: | 0 |
| EINECS: | 232-468-9 |
| Product Categories: | Inhibitors;Enzyme;BPC |
| Mol File: | Mol File |
Pancreatin Chemical Properties
| bulk density | 400kg/m3 |
| density | 1.4-1.52 |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | -20°C |
| solubility | Soluble or partly soluble in water forming a slightly turbid solution; practically insoluble in ethanol (96%) and in ether . |
| form | powder |
| color | beige |
| PH | 5-6 (20°C, 10g/L in H2O) |
| biological source | Porcine pancreas |
| Water Solubility | Soluble in water. Insoluble in alcohol and ether. |
| Merck | 13,7075 |
| Specific Activity | 8× USP specifications |
| Stability: | Stable. Incompatible with alcohols, strong acids. |
| Cosmetics Ingredients Functions | HAIR CONDITIONING SKIN CONDITIONING |
| LogP | -1.3 at 20℃ and pH5.7-5.8 |
| EPA Substance Registry System | Pancreatin (8049-47-6) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42-42/43 |
| Safety Statements | 22-24-26-36/37-37/39 |
| WGK Germany | 1 |
| RTECS | RT9033000 |
| F | 3-10 |
| Autoignition Temperature | >360°C |
| TSCA | TSCA listed |
| HS Code | 35079090 |
| Storage Class | 13 - Non Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
| Hazardous Substances Data | 8049-47-6(Hazardous Substances Data) |
| Toxicity | LD50 orl-rat: >10 g/kg YACHDS 3,2427,75 |
| Chemical Properties | cream powder |
| Chemical Properties | Pancreatin is a yellowish to cream-colored,amorphous powder with a strong odor. Slightly solublein water. Hazard Identification (based on NFPA-704 MRating System): Health 1, Flammability 1, Reactivity 0.Sparingly soluble in water. |
| History | The first observations and experimental demonstrations that pancreatin could be used to improve protein and fat digestion in animals and human patients are from the 19th century, soon after Claude Bernard had revealed the essential role of pancreatic secretion in the digestion of foods. In 1859, the dutch physician Joseph Alexander Fles showed that the daily intake of calf pancreas extract could restore the digestion of fat in a diabetic patient who suffered from diarrhea and had large amounts of fat in the stools. In 1890, Abelmann showed that the consumption of fresh pig pancreas could improve protein and fat digestion in dogs after surgical removal of the pancreas. This is considered as the first experimental demonstration of enzyme replacement[1]. |
| Uses | Hydrolyzes starch into dextrins and sugar Pancreatin from porcine pancreas is used in the treatment of steatorrhea by lipase supplementation therapy and for pancreatic diabetes. It is also used in the removal of formalin-fixed tissues from arterial grafts without causing damage in fiber integrity. Further, it finds uses in contact lenses. In addition to this, it hydrolyzes starch into dextrins and sugar. It is also used to treat conditions responsible for deficiency in pancreatic secretions, such as surgical pancreatectomy, pancreatitis and cystic fibrosis. |
| Uses | Pancreatin from porcine pancreas has been used:
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| Uses | Enzyme (digestant adjunct). |
| Brand name | Panteric (Parke-Davis). |
| Biological Functions | Pancreatin is a supplement that can result in decreased food intake. It is used for digestion, and absorption of food. Your pancreas secretes about one and one half quarts of pancreatic juice daily into the small intestine. |
| General Description | Pancreatin (Panteric) is a substance obtained from the fresh pancreas of the hog or the ox and contains a mixture of enzymes, principally pancreatic amylase (amylopsin), protease, and pancreatic lipase (steapsin). It converts not less than 25 times its weight of USP Potato Starch Reference Standard into soluble carbohydrates and not less than 25 times its weight of casein into proteoses. It acts best in neutral or faintly alkaline media, and excessive acid or alkali renders it inert. Pancreatin can be prepared by extracting the fresh gland with 25% alcohol or with water and subsequently precipitating with alcohol. Besides the enzymes mentioned, it contains some trypsinogen, which can be activated by intestinal enterokinase; chymotrypsinogen, which is converted by trypsin to chymotrypsin; and carboxypeptidase. Pancreatin is used largely for predigestion of food and for the preparation of hydrolysates. The value of its enzymes orally must be very small because they are digested by pepsin and acid in the stomach, although some of them may escape into the intestines without change. Even if they are protected by enteric coatings, it is doubtful they could be of great assistance in digestion. |
| Biochem/physiol Actions | Due to the enzymatic components such as trypsin, amylase and lipase, pancreatin hydrolyzes proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40?°C, will digest not less than 25 times its weight of casein in 60 minutes at pH7.5 at 40?°C and will release not less than 2 microequivalents of acid per min per mg pancreatin from olive oil at pH9.0 at 37?°C. |
| Safety Profile | Moderately toxic by subcutaneous and intraperitoneal routes. |
| Potential Exposure | It is an enzyme found in the pancreasand is used in medicines and in treating leather andtextiles. |
| Metabolism | Pharmacokinetic data are not available as the enzymes act locally in the gastrointestinal tract. After exerting their action, the enzymes are digested themselves in the intestine. |
| Incompatibilities | Dust may form explosive mixturewith air. Incompatible with oxidizers (chlorates, nitrates,peroxides, permanganates, perchlorates, chlorine, bromine,fluorine, etc.); contact may cause fires or explosions. Keepaway from alkaline materials, strong bases, strong acids,oxoacids, epoxides, alcohols. |
| References | [1] Amal Salhi . “Characterization of all the lipolytic activities in pancreatin and comparison with porcine and human pancreatic juices.” Biochimie 169 (2020): Pages 106-120. |
Pancreatin Preparation Products And Raw materials
| Raw materials | Germanium |
| Preparation Products | L-Tryptophan-->CITRATE SYNTHASE-->Chondroitin 4-sulfate-->Chondroitin sulfate |
