p-Cresol CAS 106-44-5
Introduction：Basic information about p-Cresol CAS 106-44-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
p-Cresol Basic informationdescription Chemical properties Uses Production method Toxicity
| Product Name: | p-Cresol |
| Synonyms: | KRESOL-PARA;phenol,-methyl-;p-Kresol;p-Methyiphenol;p-Methylhydroxybenzene;p-Oxytoluene;p-Toluol;p-Tolyl alcohol |
| CAS: | 106-44-5 |
| MF: | C7H8O |
| MW: | 108.14 |
| EINECS: | 203-398-6 |
| Product Categories: | Vaccinium myrtillus (Bilberry);Amber Glass Bottles;Analytical Reagents;Analytical Reagents for General Use;Analytical/Chromatography;Aspalathus linearis (Rooibos tea);C-D;Ephedra sinica;Nutrition Research;Phytochemicals by Plant (Food/Spice/Herb);Puriss p.a.;Building Blocks for Liquid Crystals;Functional Materials;Phenols (Building Blocks for Liquid Crystals);Solvent Bottles;Solvent Packaging Options;Solvents;Industrial/Fine Chemicals;bc0001 |
| Mol File: | 106-44-5.mol |
p-Cresol Chemical Properties
| Melting point | 32-34 °C(lit.) |
| Boiling point | 202 °C(lit.) |
| density | 1.034 g/mL at 25 °C(lit.) |
| vapor density | 3.72 (vs air) |
| vapor pressure | 1 mm Hg ( 20 °C) |
| refractive index | nD20 1.5395 |
| FEMA | 2337 | P-CRESOL |
| Fp | 193 °F |
| storage temp. | Store below +30°C. |
| solubility | 20g/l |
| form | Crystalline Solid or Liquid |
| pka | 10.17(at 25℃) |
| color | Colorless to light yellow, may darken on exposure to light |
| Specific Gravity | 1.0341 (20/4℃) |
| Odor | at 0.10 % in dipropylene glycol. phenolic narcissus animal mimosa |
| Odor Type | phenolic |
| Odor Threshold | 0.000054ppm |
| biological source | synthetic |
| explosive limit | 1%(V) |
| Water Solubility | 20 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| JECFA Number | 693 |
| Merck | 14,2579 |
| BRN | 1305151 |
| Henry's Law Constant | 6.17 at 20.00 °C, 9.31 at 25.00 °C (dynamic equilibrium system-GC, Feigenbrugel et al., 2004a) |
| Exposure limits | NIOSH REL: TWA 2.3 ppm (10 mg/m3), IDLH 250 ppm; OSHA PEL: TWA 5ppm (22 mg/m3); ACGIH TLV: TWA for all isomers 5 ppm (adopted). |
| Dielectric constant | 5.6（21.0℃） |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. Air and light-sensitive. Hygroscopic. |
| Cosmetics Ingredients Functions | ANTIMICROBIAL PERFUMING |
| Cosmetic Ingredient Review (CIR) | p-Cresol (106-44-5) |
| InChI | 1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3 |
| InChIKey | IWDCLRJOBJJRNH-UHFFFAOYSA-N |
| SMILES | Cc1ccc(O)cc1 |
| LogP | 1.94 |
| Surface tension | 35.47mN/m at 298.15K |
| CAS DataBase Reference | 106-44-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 4-methyl-(106-44-5) |
| EPA Substance Registry System | p-Cresol (106-44-5) |
Safety Information
| Hazard Codes | T,Xi |
| Risk Statements | 24/25-34-39/23/24/25-23/24/25 |
| Safety Statements | 36/37/39-45-36/37 |
| OEB | B |
| OEL | TWA: 2.3 ppm (10 mg/m3) |
| RIDADR | UN 3455 6.1/PG 2 |
| WGK Germany | 1 |
| RTECS | GO6475000 |
| F | 8 |
| Autoignition Temperature | 555 °C |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29071200 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Oral Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1B |
| Hazardous Substances Data | 106-44-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 1.8 g/kg (Deichmann, Witherup) |
| description | p-Cresol is a low-molecular-weight compound, is a starting material in the synthesis of bupranolol which is a non-selective beta blocker. p-cresol is found in extracts from the plants Mentha pulegium and Hedeoma pulegioides, commonly known as pennyroyal oil and pennyroyal tea. These extracts are popular as unconventional herbal therapeutic agents and are applied as abortiva, diaphoretics, emmenagogues, and psychedelic drugs. Pennyroyal oil is extensively used for its pleasant mint-like smell in the flavoring industry. It is also used in the production of antioxidants like butylated hydroxytoluene. Furthermore, it is used as an adhesive and a sealant in chemicals, dyes, intermediates, odor agents, plasticizers, plating agents and surface treating agents. It acts as an antioxidant and a disinfectant in pharmaceuticals. |
| Chemical properties | It appears as colorless to pink crystal with smoked and herbal smell. The relative density (d420) is 1.0178; the refractive index (nD20) is 1.5312; the melting point is 34.8 °C; the boiling point is 201.9 °C and the flash point is 86.1 °C. It is soluble in water (2.3%/40 ℃), easily soluble in caustic soda and common organic solvents. Natural products exist in ylang oil, strawberry, cheese, coffee and cocoa and so on. |
| Uses | 1. It can be used as germicide, fungicide. Used for organic Synthesis. 2. This product is the raw material for the manufacture of antioxidant 2,6-di-tert-butyl-p-cresol and rubber antioxidant. At the same time, it is also an important fundamental raw material for the production of pharmaceutical TMP and dyes para-Cresidine sulfonic acid. 3. P-cresol is the intermediate for the manufacturing of fungicide methylphosophos, an insecticide flufenvalerate, and Etofenprox, but also the intermediate of antioxidant additives 2, 6-di-tert-butyl-4-methyl phenol and p-hydroxybenzene formaldehyde. 4. It can be used as raw materials for the preparation of antioxidant 264 (2, 6-di-tert-butyl-p-cresol) and rubber antioxidant. In the plastics industry, it can produce phenolic resin and plasticizer. In medicine, it can be used as a disinfectant. In addition, it can be used as the raw materials of dyes and pesticides. |
| Production method | Production method of p-Cresol: sulfonate toluene with sulfuric acid to get p-toluenesulfonic acid, after cooling, crystallization, filtration, and then add sodium sulfite to neutralize to get sodium p-toluenesulfonate, and then sodium hydroxide alkaline melting to get sodium p-toluene phenol, and then acidified by sulfurous acid to become. Finally, it is separated by distillation and crystallization. |
| Toxicity | Central nervous system: toxic effects with being fatal in severe cases. LD50:1800 mg/kg (rat, oral); As fragrances, it can be safely used in food (FDA, §172.515, 2000); GRAS (FEMA). |
| Chemical Properties | Cresol is a mixture of three isomeric forms: o-, m-, and p-cresol. These compounds are slightly soluble in water. The m-isomer is a colorless or yellow liquid with characteristic odor. The p-cresol is a colorless to pink crystals with a characteristics phenol-like odor. The concentration at which the odor becomes detectable in water is 55 parts per billion (Buttery et al., 1988). Another study by Leonardos et al. (1969) reported an experimental odor threshold concentration of 1 parts per billion, which is higher than the 0.054 parts per billion reported by Nagata and Takeuchi (1990). |
| Occurrence | Has been found in a score of essential oils including ylang ylang and oil of jasmine (Gildemeister & Hoffman, 1966). |
| Uses | p-Cresol is utilized in the production of artificial resins, liquid crystal intermediates, disinfectants, fumigants, and as an industrial solvent. It is also involved in the manufacturing of Bupranolol, a non-selective beta blocker. |
| Definition | ChEBI: P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. It has a role as a uremic toxin, a human metabolite and an Escherichia coli metabolite. |
| Preparation | It can be prepared by fractional distillation of coal tar where it occurs together with the ortho- and para- isomers. |
| Production Methods | The cresols (cresylic acids) are methyl phenols and generallyappear as a mixture of isomers. p-Cresol is a 4-methylderivative of phenol and is prepared from m-toluic acidor obtained from coal tar or petroleum. Crudecresol is obtained by distilling “gray phenic acid” at atemperature of ～180–201°C. p-Cresol may be separatedfrom the crude or purified mixture by repeated fractionaldistillation in vacuo. It can also be prepared synthetically bydiazotization of the specific toluene or by fusion of thecorresponding toluenesulfonic acid with sodium hydroxide. |
| Aroma threshold values | Detection: 55 to 100 ppb. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 81, p. 4230, 1959 DOI: 10.1021/ja01525a028 Chemical and Pharmaceutical Bulletin, 31, p. 749, 1983 DOI: 10.1248/cpb.31.749 Tetrahedron Letters, 21, p. 3731, 1980 DOI: 10.1016/0040-4039(80)80164-X |
| General Description | Colorless solid with a tar like odor. Sinks and mixes slowly with water. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | p-Cresol is sensitive to heat. p-Cresol is also sensitive to light. p-Cresol is incompatible with strong oxidizers and strong alkalis. p-Cresol will attack some forms of plastics, coatings and rubber. |
| Health Hazard | INHALATION: Irritation of nose or throat. EYES: Intense irritation and pain, swelling of conjunctiva and corneal damage may occur. SKIN: Intense burning, loss of feeling, white discoloration and softening. Gangrene may occur. INGESTION: Burning sensation in mouth and esophagus. Vomiting may result. Absorption by all routes may cause muscular weakness, gastroenteric disturbance, severe depression and collapse. Effects are primarily on central nervous system, edema of lungs, injury of spleen and pancreas may occur. |
| Safety Profile | Poison by ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. A severe skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data by itself and with 7,12-dirnethyl benz(a)anthracene. Combustible when exposed to heat or flame. Moderately explosive in the form ofvapor when exposed to heat or flame. To fight fire, use CO2, dry chemical, alcohol foam. See also other cresol entries and PHENOL. |
| Potential Exposure | Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol. |
| Carcinogenicity | o-Cresol has been induced a fewpapillomas but no carcinomas in tumor studies. |
| Source | As 3+4-methylphenol, detected in distilled water-soluble fractions of 87 octane gasoline(6.03 mg/L), 94 octane gasoline (0.60 mg/L), Gasohol (1.76 mg/L), No. 2 fuel oil (1.84 mg/L), jetfuel A (0.43 mg/L), diesel fuel (1.318 mg/L), and military jet fuel JP-4 (0.92 mg/L) (Potter, 1996). A high-temperature coal tar contained 4-methylphenol at an average concentration of 0.27 wt %(McNeil, 1983). Occurs naturally in brown juniper, Spanish cedar, peppermint (2 to 20 ppb), tarragon, asparagusshoots, ylang-ylang, jasmine, tea leaves, coffee beans, Japanese privet, white mulberries,raspberries, vanilla, blueberries, sour cherries, anise, and tamarind (Duke, 1992). A liquid swine manure sample collected from a waste storage basin contained 4-methylphenolat a concentration of 4.9 mg/L (Zahn et al., 1997). |
| Metabolism | p-Cresol is oxidized at the methyl group in both dogs and rabbits to yield ρ-hydroxybenzoic acid. In the rabbit up to 10% of oral doses of 0.25-0.5 g is excreted as free and conjugated p-hydroxybenzoic acid (Williams, 1959). |
| Shipping | UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material. |
| Purification Methods | It can be separated from m-cresol by fractional crystalisation of its melt. Purify it by distillation, by precipitation from *benzene solution with pet ether, and via its benzoate, as for phenol. Dry it under vacuum over P2O5. It has also been crystallised from pet ether (b 40-60o) and by conversion to sodium p-cresoxyacetate which, after crystallisation from water is decomposed by heating with HCl in an autoclave [Savard Ann Chim (Paris) 11 287 1929]. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 189o. [Beilstein 6 II 2093.] |
| Incompatibilities | Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals. |
| Toxics Screening Level | The initial threshold screening level (ITSL) for Cresol has been derived 100 μg/m3 based on an 8-hour averaging time. |
| Waste Disposal | Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators. |
p-Cresol Preparation Products And Raw materials
| Raw materials | Sodium nitrite-->p-Toluenesulfonic acid-->m-Cresol-->Cresol-->o-Cresol-->Naphthol AS-OL-->Sodium p-toluenesulfonate-->2-METHYLANILINE SULFATE-->PHENOLPHTHALIN-->m-cresol and p-cresol mixture |
| Preparation Products | m-Cresol-->4-Hydroxybenzaldehyde-->p-Anisaldehyde-->ETHYL 4-ETHOXYPHENYLACETATE-->2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester-->3,5-DIMETHYL-BENZOFURAN-2-CARBOXYLIC ACID-->2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol-->Butylated Hydroxytoluene-->Ethyl 3,5-dimethylbenzofuran-2-carboxylate ,95%-->4-Methylanisole-->1-(2-Hydroxy-5-methylphenyl)ethanone-->4-CHLOROMETHYL-6-METHYL-CHROMEN-2-ONE-->Mn(Ⅲ)salen epoxidation catalyst-->Tolterodine-->2-HYDROXY-5-METHYLISOPHTHALALDEHYDE-->p-Tolyl phenylacetate-->2-tert-Butyl-4-methylphenol-->2-[[4-[[4-[bis(2-hydroxyethyl)amino]-6-chloro-1,3,5-triazin-2-yl]amino]phenyl]azo]-p-cresol-->Acid Orange 116-->Neutral Brown Rl-->2-Bromo-4-methylphenol-->P-TOLYL ISOBUTYRATE-->P-TOLYL ACETATE |
