Introduction：Basic information about Phthalazine CAS 253-52-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Phthalazine Basic information
| Product Name: | Phthalazine |
| Synonyms: | 2,3-Diazanaphthalene;beta-Phenodiazine;β-Phenodiazine;4,5-BENZOPYRIDAZINE;2,3-BENZODIAZINE;BENZO[D]PYRIDAZINE;PHTHALAZINE;PHZ |
| CAS: | 253-52-1 |
| MF: | C8H6N2 |
| MW: | 130.15 |
| EINECS: | 205-963-2 |
| Product Categories: | Building Blocks;Heterocyclic Building Blocks;Pyridazines |
| Mol File: | 253-52-1.mol |
|
Phthalazine Chemical Properties
| Melting point | 89-92 °C(lit.) |
| Boiling point | 189 °C29 mm Hg(lit.) |
| density | 1.1509 (rough estimate) |
| refractive index | 1.6231 (estimate) |
| Fp | 178-180°C/15mm |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 3.47(at 20℃) |
| form | Crystalline Powder |
| color | Slightly brown to beige |
| Water Solubility | Soluble in water, methanol, chloroform. |
| Merck | 14,7370 |
| BRN | 109240 |
| InChI | 1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H |
| InChIKey | LFSXCDWNBUNEEM-UHFFFAOYSA-N |
| SMILES | c1ccc2cnncc2c1 |
| CAS DataBase Reference | 253-52-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Phthalazine(253-52-1) |
| EPA Substance Registry System | Phthalazine (253-52-1) |
Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-68 |
| Safety Statements | 24/25-37/39-36-26-36/37/39 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 3
Muta. 2 |
Phthalazine Usage And Synthesis
| Chemical Properties | SLIGHTLY BROWN TO BEIGE CRYSTALLINE POWDER |
| Uses | Phthalazine is a heterocyclic organic compound isomeric with quinoxaline, cinnoline and quinazoline. Aminophthalazine compounds serve as effective phosphodiesterase (PDE) inhibitors. |
| Uses | Phthalazine derivatives including copper and platinum complexes were induce the apoptosis in breast cancer cell lines and renal hyperemia. |
| Definition | ChEBI: Phthalazine is an azaarene that is the 2,3-diaza analogue of naphthalene. The parent of the class of phthalazines. It is a mancude organic heterobicyclic parent, a member of phthalazines, an azaarene and an ortho-fused heteroarene. |
| Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 2, p. 206, 1965 DOI: 10.1002/jhet.5570020219 |
| Purification Methods | Phthalazine crystallises from diethyl ether or *benzene, and sublimes under a vacuum. The hydrochloride forms needles from EtOH with m 235-236o(dec) and the picrate has m 208-210o. [Armarego J Appl Chem 11 70 1961, Beilstein 23 H 174, 23 III/IV 1233.] |
Phthalazine Preparation Products And Raw materials
| Preparation Products | 1-CHLOROPHTHALAZINE-->Hyaluronidase-->Cadralazine-->Ophthazin-->2-Ethyl-3-methylnaphthalene |
