Introduction：Basic information about Pipecuronium bromide CAS 52212-02-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Pipecuronium bromide Basic information
| Product Name: | Pipecuronium bromide |
| Synonyms: | pipecuronium bromide;4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide;4,4'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetoxy)androstane-2,16-diyl]bis[1,1-dimethylpiperazinium] dibromide;PIPECURIUM BROMIDE;Pipecuronium;PIPECURINIUM BROMIDE;4，4’-[(2β，3α，5α，16β，17β)-3，17-Bis(acetoxy)andrc~tane-2，16-diyl]bis(1，1-dimethylpiperazinium)dibromide;Ardtm |
| CAS: | 52212-02-9 |
| MF: | C35H62Br2N4O4 |
| MW: | 762.69918 |
| EINECS: | 257-740-4 |
| Product Categories: | |
| Mol File: | 52212-02-9.mol |
|
Pipecuronium bromide Chemical Properties
| Melting point | 262-264° (dec) |
| alpha | D25 +8.1° (c = 1 in water) |
| storage temp. | Store at -20°C |
| solubility | DMSO, Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChIKey | TXWBOBJCRVVBJF-LQDGISGANA-L |
| CAS DataBase Reference | 52212-02-9(CAS DataBase Reference) |
Safety Information
| Toxicity | LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro) |
Pipecuronium bromide Usage And Synthesis
| Chemical Properties | Crystallized from dichloromethane? Crystallized from acetone, melting point 262-264°C (decomposition). [alpha] D23+8.1° (C=1, water). Acute Toxicity LD50 Mice, Rats (mg/kg): 29.7, 172.6 IV; 70.6, 449.6 Intraperitoneal. |
| Uses | Pipecuronium Bromide is a muscle relaxant and an anaesthesia used in patients undergoing coronary artery bypass graft surgery. |
| Definition | ChEBI: Pipecuronium bromide is a steroid ester. |
| Brand name | Arduan (Organon). |
| General Description | Pipecurium bromide, 4,4 -(3 ,17 -dihydroxy-5 -androstan-2 ,16 -ylene)bis(1,1-dimeth-ylpiperazinium)dibromide diacetate (Arduan), is anondepolarizing muscle relaxant similar, both chemicallyand clinically, to pancuronium bromide. It is a long-actingdrug indicated as an adjunct to anesthesia and in patients undergoingmechanical ventilation. |
| Pharmacology | Pipecuronium bromide, an analogue of pancuronium, was developed inHungary in 1980 and is marketed in Eastern Europe and the United S tates.The intubating dose is 0.07 mg kg–1. The onset time and time to recovery fromblock are similar to those of pancuronium, and excretion ofthe drug through the kidneys is significant (66%). In contrast topancuronium, pipecuronium produces marked cardiovascular stability,having no vagolytic or sympathomimetic effects. It may therefore be usefulduring major surgery in patients with cardiac disease. |
Pipecuronium bromide Preparation Products And Raw materials
| Raw materials | Tetrahydrofuran-->Chloroform-->Magnesium sulfate-->Hexane-->Sodium borohydride-->Erythromycin Estolate-->Isopropenyl acetate-->Perbenzoic acid |
