PIPERACILLIN CAS 66258-76-2

Introduction：Basic information about PIPERACILLIN CAS 66258-76-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

PIPERACILLIN Basic information

• Product Name: PIPERACILLIN
• Synonyms: (2s,5r,6r)-6-[[(2r)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;Piperacillin (500 mg);Piperacillin (350 mg);Piperacillin hydrat;Piperacillin CRS;PIPERACILLIN USP/EP/BP;Piperacillin (1541500);Piperacillin Hydrate
• CAS: 66258-76-2
• MF: C23H29N5O8S
• MW: 535.57
• EINECS: 811-368-4
• Mol File: 66258-76-2.mol

PIPERACILLIN Chemical Properties

• solubility: Slightly soluble in water, freely soluble in methanol, slightly soluble in ethyl acetate.
• Major Application: pharmaceutical (small molecule)
• InChIKey: NBXPLBPWMYNZTC-IDYPWDAWSA-N
• SMILES: S1[C@H]2N([C@H](C1(C)C)C(=O)O)C(=O)[C@H]2NC(=O)[C@H](NC(=O)N4CCN(C(=O)C4=O)CC)c3ccccc3.O

Safety Information

• WGK Germany: WGK 3
• HS Code: 2941106000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Chronic 3 Skin Sens. 1B

PIPERACILLIN Usage And Synthesis

Chemical Properties

White or almost white powder.

Uses

Penicillin antibacterial.

in vivo

Piperacillin (100 mg/kg, i.v., 4 times a day, 5 d) hydrate in combination with Tazobactam (HY-B1418)(12.5 mg/kg, i.v., 4 times a day, 5 d) prolongs survival in mice with low inoculum of K. pneumoniae^[3].

• Animal Model: BALB/c low inoculum model of K. pneumoniae, KEN-11 strain^[3].
• Dosage: 100 mg/kg
• Administration: Intravenous injection (i.v.), 4 times a day, 5 d, in combination with Tazobactam (12.5 mg/kg, i.v., 4 times a day, 5 d)
• Result: Enabled all mice survived whereas all control mice died by 5 d, decreased the number of bacteria in lungs compared with control group. Observed no bacteria in the blood of most mice (except for two mice at the early phase) while bacteria were observed in the blood of control group. Observed few inflammatory cells in the alveoli whereas an influx of numerous inflammatory cells were observed in the control group.