Procaterol hydrochloride CAS 81262-93-3

Introduction：Basic information about Procaterol hydrochloride CAS 81262-93-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Procaterol hydrochloride Basic information

• Product Name: Procaterol hydrochloride
• Synonyms: PROCATEROL HEMIHYDRATE;PROCATEROL HYDROCHLORIDE HEMIHYDRATE;PROCATEROL HCL HEMIHYDRATE;(R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone hydrochloride;Procaterol hydrochloride;Procaterol hydrochlride hemihydrate;8-hydroxy-5-[(1S,2R)-1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one hydrate dihydrochloride;Hydrochloride hemihydrate
• CAS: 81262-93-3
• MF: C16H25ClN2O4
• MW: 344.83
• EINECS: 263-763-0
• Product Categories: Aromatics;API;Other APIs;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 81262-93-3.mol

Procaterol hydrochloride Chemical Properties

• Melting point: 193-197° (dec)
• storage temp.: Refrigerator, Under Inert Atmosphere
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic
• CAS DataBase Reference: 81262-93-3(CAS DataBase Reference)

Safety Information

• Toxicity: LD50 of the hydrochloride in male rats (mg/kg): 2600 orally, 80 i.v. (Nakagawa)

Procaterol hydrochloride Usage And Synthesis

Uses

Procaterol hydrochloride can be used as short-acting β2-adrenergic receptor agonist used to treat asthma.

Uses

Short-acting β2-adrenergic receptor agonist used to treat asthma.

Brand name

Pro-Air (Parke-Davis).

in vivo

Procaterol hydrochloride hemihydrate (1, 3 or 10 μg/mL, inhaled administration) inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation^[2].
Procaterol hydrochloride hemihydrate (0.1 mg/kg, i.p.) completely abolishes both the Mch-induced cough in conscious guinea pigs^[3].

• Animal Model: Allergic inflammatory guinea-pig model^[2]
• Dosage: 1, 3 or 10 μg/mL
• Administration: Inhaled administration
• Result: Inhibited histamine-induced airflow obstruction and microvascular leakage.